Evidence map›Paper›PMID 40435257›Full record

ArticleScience advances2025

Tumor microenvironment-activated Zn//MnO

Xiaoran Ding, Xiaoteng Jia, Hongming Yuan, Daxin Pang, Hualu Zhao, Peng Sun, Fangmeng Liu, Danming Chao, Meiying Xin, Caiyun Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Biointegrated Battery-Based Electroceuticals.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  4. Article
  5. Article
  6. Synergistic Mn-MOF Activation of Pistol Ribozymes for Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoran DingState Key Laboratory of Integrated Optoelectronics, JLU Region, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.ORCID 0009-0003-6752-5717
Xiaoteng JiaState Key Laboratory of Integrated Optoelectronics, JLU Region, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.ORCID 0000-0001-5630-8838
Hongming YuanCollege of Animal Sciences, Jilin University, Changchun 130062, China.ORCID 0000-0002-0809-5599
Daxin PangCollege of Animal Sciences, Jilin University, Changchun 130062, China.
Hualu ZhaoState Key Laboratory of Integrated Optoelectronics, JLU Region, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.
Peng SunState Key Laboratory of Integrated Optoelectronics, JLU Region, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.
Fangmeng LiuState Key Laboratory of Integrated Optoelectronics, JLU Region, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.
Danming ChaoCollege of Chemistry, Jilin University, Changchun 130012, China.
Meiying XinDepartment of Pediatric Neurology, Children's Medical Center, The First Hospital of Jilin University, Changchun 130021, China.ORCID 0000-0002-7645-8515
Caiyun WangIntelligent Polymer Research Institute, Faculty of Engineering and Information Sciences, University of Wollongong, North Wollongong, NSW 2500, Australia.ORCID 0000-0001-9539-2155
Geyu LuState Key Laboratory of Integrated Optoelectronics, JLU Region, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.ORCID 0000-0003-1958-2867
Gordon WallaceIntelligent Polymer Research Institute, Faculty of Engineering and Information Sciences, University of Wollongong, North Wollongong, NSW 2500, Australia.ORCID 0000-0002-0381-7273

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal ions are widely adopted to potentiate oxidative damage-induced immunogenic cell death (ICD) and regulate immune pathways. However, current ion delivery platforms lack precise administration over distribution and retention time within the tumor microenvironment, leading to high systemic toxicity and suboptimal therapeutic efficacy. Here, local electrochemical immunotherapy is developed by implanting a tumor microenvironment-activated Zn//MnO

Indexed as

ImmunotherapyManganese CompoundsNeoplasmsOxidesTumor MicroenvironmentZincAnimalsCell Line, TumorElectrochemical TechniquesHumansMiceReactive Oxygen SpeciesManganese Compoundsmanganese dioxidemanganese oxideOxidesReactive Oxygen SpeciesZinc

Identifiers

PMID40435257
PMCPMC12118630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.