Evidence map›Paper›PMID 40435251›Full record

ArticleScience advances2025

FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia.

Hao Huang, Xinlu Li, Jinlian Luo, Chuan Gao, Mengjie Yang, Jin Xu, Ting Xie, Zhi Chen, Donghai Wang, Yuan Wang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. FTO depletion does not alter mbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hao HuangDepartment of Hematology, Zhongnan Hospital of Wuhan University, State Key Laboratory of Metabolism and Regulation in Complex Organisms, Wuhan University, Wuhan, China.ORCID 0000-0002-3144-809X
Xinlu LiFrontier Science Center of Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Jinlian LuoFrontier Science Center of Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Chuan GaoFrontier Science Center of Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Mengjie YangFrontier Science Center of Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Jin XuFrontier Science Center of Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Ting XieFrontier Science Center of Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.
Zhi ChenFrontier Science Center of Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.ORCID 0009-0003-4801-1331
Donghai WangFrontier Science Center of Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.ORCID 0000-0001-6119-8557
Yuan WangDepartment of Physiology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Hua-Bing LiShanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-3573-6803
Jinyan HuangCenter for Biomedical Big Data, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0002-8053-0209
Yu LiuPediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0001-8928-2558
Haojian ZhangFrontier Science Center of Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.ORCID 0000-0002-9394-9383
Panagiotis NtziachristosLeukemia Therapy Resistance Lab, Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.ORCID 0000-0001-6374-8954
Yun ZhaoCyrus Tang Medical Institute, National Clinical Research Center for Hematologic Diseases, Soochow University, Suzhou, China.ORCID 0000-0002-0065-4675
Guoliang QingFrontier Science Center of Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.ORCID 0000-0002-7892-2860
Hudan LiuDepartment of Hematology, Zhongnan Hospital of Wuhan University, State Key Laboratory of Metabolism and Regulation in Complex Organisms, Wuhan University, Wuhan, China.ORCID 0000-0003-1362-6048

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the regulation of N6-methyladenosine (m

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOLeukemia, T-CellPrecursor T-Cell Lymphoblastic Leukemia-LymphomaAdenosineAlkB Homolog 5, RNA DemethylaseAnimalsCell Line, TumorGene Expression Regulation, LeukemicGlycolysisHumansMiceRNA, MessengerRNA StabilityAdenosineAlkB Homolog 5, RNA DemethylaseAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanN-methyladenosineRNA, Messenger

Identifiers

PMID40435251
PMCPMC12118595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.