ArticleThe British journal of radiology2025
Quantified motility in Crohn's disease to evaluate stricture composition using cine-MRI.
Article in The British journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The CONTEXT trial: Real world clinical use of GIQuant-a motility MRI based activity biomarker for small bowel Crohn's disease.Journal of Crohn's & colitis · 2026Article
- The Evolving Role of Cine MRI in Crohn's Disease: From Functional Motility Analysis to Precision Management: A Review of the Last 10 Years.Diagnostics (Basel, Switzerland) · 2025Review
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14 authors.
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Abstract
objectivesThe histopathological composition of a stricture impacts clinical treatment choice. Therefore, imaging biomarkers that can distinguish a predominantly inflammatory from a chronic (i.e., non-inflammatory) stricture are highly relevant. The aim of our study was to determine whether it is possible to distinguish inflammatory (i.e., inflammatory and mixed) from chronic (i.e., non-inflammatory) strictures using quantified motility measured on cine-MRI in Crohn's disease (CD) patients.
methodsIn this prospective cross-sectional study, consecutive CD patients scheduled for small bowel resection underwent 2D cine-MRI prior to surgery. The motility of small bowel strictures and pre-stricture dilatations was quantified using a validated post-processing method (GIQuant). The resection specimens were scored by two pathologists as either: predominantly inflammatory, mixed, or predominantly chronic (i.e., non-inflammatory). For the analysis, strictures were stratified into inflammatory strictures (i.e., predominantly inflammatory and mixed) and chronic (i.e., non-inflammatory) strictures.
resultsTwenty-eight patients were included with 30 strictures and 15 pre-stricture dilatations. Pre-stricture dilatation motility was higher for chronic (i.e., non-inflammatory) compared to inflammatory (i.e., inflammatory and mixed) strictures (289.5 AU [188.0-362.9] vs. 113.1 AU [83.6-142.4], P = .004). The area under the curve (AUC) for chronic (i.e., non-inflammatory) stricture detection was 0.93 (95% CI, 0.78-1.0, P = .01). Within strictures, no difference was found between motility in different histopathology categories (P = .6).
conclusionMotility in the pre-stricture dilatations of chronic (i.e., non-inflammatory) strictures was higher compared to inflammatory (i.e., inflammatory and mixed) strictures. No difference in motility was observed in stricture motility among stricture subtypes. Our findings suggest that quantified motility-measured with cine-MRI-of pre-stricture dilatations could possibly distinguish chronic (i.e., non-inflammatory) strictures from inflammatory (i.e., inflammatory and mixed) strictures. ADVANCES IN KNOWLEDGE: Motility measured with cine-MRI could provide an imaging biomarker for the distinction between chronic (i.e., non-inflammatory) and inflammatory (i.e., inflammatory and mixed) strictures in CD.
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