Evidence map›Paper›PMID 40434889›Full record

ArticleCell reports2025

Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodes.

Brandon M Ruszala, Marc H Schieber

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Integration of learned artificial sensation with vision during freely moving navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brandon M RuszalaDepartment of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
Marc H SchieberDepartment of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.

Funding

Injecting instructions using intracortical microstimulation in association cortexR01NS107271 · NINDS · UNIVERSITY OF ROCHESTER · PI SCHIEBER, MARC H · 2018 to 2022
$2.1M
Effects of Intracortical Microstimulation on Neural Activity in Distant Cortical RegionsF31NS129099 · NINDS · UNIVERSITY OF ROCHESTER · PI RUSZALA, BRANDON MICHAEL · 2022 to 2024
$95k
NINDS NIH HHS F31 NS129099NINDS NIH HHS R01 NS107271
6 · The paper itself

Abstract

Although control of movement involves many cortical association areas, bidirectional brain-machine interfaces (BMIs) typically decode movement intent from the motor cortex and deliver feedback information to the primary somatosensory cortex (S1). Compared to the S1, the parietal and premotor areas encode more complex information about object properties, hand pre-shaping, and reach trajectories. BMIs therefore might deliver richer information to those cortical association areas than to primary areas. Here, we investigated whether instructions for a center-out task could be delivered via intracortical microstimulation (ICMS) in the anterior intraparietal area (AIP), dorsal posterior parietal cortex (dPPC), or dorsal premotor cortex (PMd) as well as the ventral premotor cortex (PMv) and S1. Two monkeys successfully learned to use AIP, PMv, or S1-ICMS instructions, but neither learned to use dPPC- or PMd-ICMS instructions. The AIP, PMv, and S1 may thus be effective cortical territory for delivering information to the brain, whereas the dPPC or PMd may be comparatively ineffective.

Indexed as

Hand StrengthMotor CortexParietal LobeSomatosensory CortexAnimalsBrain-Computer InterfacesElectric StimulationMacaca mulattaMaleMovementanterior intraparietalbrain-computer interfacebrain-machine interfacebrain stimulationCP: Neurosciencedistinguishable experiencesdorsal premotorintracortical microstimulationposterior parietalprimary somatosensoryventral premotor

Identifiers

PMID40434889
PMCPMC12169894

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.