Evidence map›Paper›PMID 40434643›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Allelic variations and gene cluster modularity act as nonlinear bottlenecks for cholera emergence.

Mario López-Pérez, Deepak Balasubramanian, Alicia Campos-Lopez, Cole Crist, Trudy-Ann Grant, Jose M Haro-Moreno, Asier Zaragoza-Solas, Salvador Almagro-Moreno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mario López-Pérez *Burnett School of Biomedical Sciences, College of Medicine, University of Central, Florida, Orlando, FL, 32827.ORCID 0000-0002-3996-6780
Deepak Balasubramanian *Burnett School of Biomedical Sciences, College of Medicine, University of Central, Florida, Orlando, FL, 32827.
Alicia Campos-LopezBurnett School of Biomedical Sciences, College of Medicine, University of Central, Florida, Orlando, FL, 32827.ORCID 0009-0008-6267-2220
Cole CristBurnett School of Biomedical Sciences, College of Medicine, University of Central, Florida, Orlando, FL, 32827.
Trudy-Ann GrantBurnett School of Biomedical Sciences, College of Medicine, University of Central, Florida, Orlando, FL, 32827.
Jose M Haro-MorenoMicrobial Genomics and Evolution Group, División de Microbiología, Universidad Miguel Hernández, Alicante 03550, Spain.ORCID 0000-0002-2113-9269
Asier Zaragoza-SolasMicrobial Genomics and Evolution Group, División de Microbiología, Universidad Miguel Hernández, Alicante 03550, Spain.ORCID 0000-0003-0913-1093
Salvador Almagro-MorenoBurnett School of Biomedical Sciences, College of Medicine, University of Central, Florida, Orlando, FL, 32827.ORCID 0000-0002-1121-1204

Funding

Burroughs Wellcome Fund (BWF) 1021977Ministerio de Economía y Competitividad (MEC) PID2023-150293NB-I00NSF (NSF) 2045671
6 · The paper itself

Abstract

The underlying factors that lead to specific strains within a species to emerge as human pathogens remain mostly enigmatic. The diarrheal disease cholera is caused by strains from a phylogenetically confined group within the

Indexed as

CholeraGenetic VariationMultigene FamilyVibrio choleraeAllelesEvolution, MolecularGenome, BacterialHumansPhylogenyallelic variationsenvironmental reservoirsmodularitypathogen emergenceVibrio cholerae

Identifiers

PMID40434643
PMCPMC12146696

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.