Evidence map›Paper›PMID 40434638›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Viral and host network analysis of the human cytomegalovirus transcriptome in latency.

Donna Collins-McMillen, Diogo De Oliveira Pessoa, Kristen Zarrella, Christopher J Parkins, Michael Daily, David R McKinzey, Nathaniel J Moorman, Jeremy P Kamil, Patrizia Caposio, Megha Padi and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Cancer viroimmunotherapy platforms based on varicella-zoster virus and cytomegalovirus.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Viral and host network analysis of the human cytomegalovirus transcriptome in latency.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Donna Collins-McMillenBioscience Innovation Organization Five Disciplines (BIO5) Institute, University of Arizona, Tucson, AZ 85719.ORCID 0000-0001-6593-1912
Diogo De Oliveira PessoaBioinformatics Shared Resource, Arizona Cancer Center, University of Arizona, Tucson, AZ 85719.
Kristen ZarrellaDepartment of Immunobiology, University of Arizona, Tucson, AZ 85719.ORCID 0000-0003-3142-6664
Christopher J ParkinsVaccine and Gene Therapy Institute, Oregon Health Science University, Beaverton, OR 97006.
Michael DailyVaccine and Gene Therapy Institute, Oregon Health Science University, Beaverton, OR 97006.
David R McKinzeyBioscience Innovation Organization Five Disciplines (BIO5) Institute, University of Arizona, Tucson, AZ 85719.ORCID 0000-0003-0845-5352
Nathaniel J MoormanDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0003-4952-6858
Jeremy P KamilDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71103.ORCID 0000-0001-8422-7656
Patrizia CaposioVaccine and Gene Therapy Institute, Oregon Health Science University, Beaverton, OR 97006.ORCID 0000-0001-7579-849X
Megha PadiBioinformatics Shared Resource, Arizona Cancer Center, University of Arizona, Tucson, AZ 85719.ORCID 0000-0002-3446-4562
Felicia D GoodrumBioscience Innovation Organization Five Disciplines (BIO5) Institute, University of Arizona, Tucson, AZ 85719.ORCID 0000-0002-6646-7290

Funding

The Administrative CoreP01AI127335 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Patrizia Caposio · 2017 to 2026
$24.6M
Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic CellsR01AI079059 · NIAID · UNIVERSITY OF ARIZONA · PI GOODRUM, FELICIA D · 2008 to 2018
$4.4M
Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic CellsR37AI079059 · NIAID · UNIVERSITY OF ARIZONA · PI Felicia D Goodrum · 2019 to 2026
$3.3M
Molecular Switch Regulating Human Cytomegalovirus Replicative and Latent StatesR01AI143191 · NIAID · UNIVERSITY OF ARIZONA · PI GOODRUM, FELICIA D, KAMIL, JEREMY PHILLIP · 2018 to 2022
$2.7M
Unraveling the regulatory circuits that drive Merkel cell carcinomaR01CA251729 · NCI · UNIVERSITY OF ARIZONA · PI PADI, MEGHA · 2021 to 2025
$1.7M
American Heart Association (AHA) 18POST33960140HHS | NIH (NIH) AI079059HHS | NIH (NIH) AI127335HHS | NIH (NIH) AI143191HHS | NIH (NIH) CA251729NCI NIH HHS R01 CA251729NIAID NIH HHS P01 AI127335NIAID NIH HHS R01 AI079059NIAID NIH HHS R01 AI143191NIAID NIH HHS R37 AI079059
6 · The paper itself

Abstract

The human cytomegalovirus (HCMV)

Indexed as

CytomegalovirusTranscriptomeVirus LatencyCytomegalovirus InfectionsGene Expression Regulation, ViralGene Regulatory NetworksHost-Pathogen InteractionsHumansTHP-1 CellsViral ProteinsViral Proteinshuman cytomegaloviruslatencyreactivationRNAseqtranscriptome

Identifiers

PMID40434638
PMCPMC12146695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.