ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2025
Two-arm study of sarcopenia in geriatric patients with high-grade glial tumors: temporal muscle thickness and prognostic nutritional index.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze the prognostic significance of temporal muscle thickness (TMT) and prognostic nutritional index (PNI) in the assessment of sarcopenia in patients diagnosed with glioblastoma multiforme (GBM) in the geriatric age group.
methodsThis study included a total of 50 patients (≥65 years of age) receiving radiotherapy (RT)/radio-chemotherapy (RCT) at Kayseri City Education and Research Hospital. We calculated TMT from cranial magnetic resonance imaging (MRI) at the time of diagnosis and PNI from laboratory measurements. To determine the cut-off values, we used the ROC analysis. The combined group (CG) was formed according to TMT and PNI.
resultsMedian overall survival (OS) was 5 months. OS for those with TMT < 6.75 mm and ≥ 6.75 mm was 5 months and 11 months, respectively (p < 0.001). OS for those with PNI < 48.87 mm and ≥ 48.87 mm was 5 months and 11 months, respectively (p = 0.026). Survival analysis showed a dramatic difference in CG between groups 1 and 4 (16 months vs. 4 months, p < 0.001). Correlations were observed between TMT and age, excision type and OS (r = 0.406 p = 0.003, r = 0.346 p = 0.014, r = 0.345 p = 0.014). Univariate Cox regression analysis showed that age, excision type, diagnosis type, RT history, initial tumor volume (ITV), TMT, PNI, CG, and albumin had an effect on survival (p values 0.017, <0.001, <0.001, <0.001, 0.011, <0.001, 0.041, 0.001, and 0.018, respectively). Multivariate Cox regression analysis showed that excision type, RT history, ITV, albumin, and CG were independent factors affecting survival (p values 0.007, 0.05, 0.005, 0.029, and 0.014, respectively).
conclusionAlthough both parameters individually have a prognostic effect in geriatric GBM patients, their combined effect as a single parameter has a much stronger impact on prognosis.
Indexed as
Identifiers
40434520What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.