Evidence map›Paper›PMID 40434519›Full record

ReviewArchives of microbiology2025

Protein kinase G-a key regulator of pathogenesis in Mycobacterium tuberculosis infection.

Anjali K Mahato, Rupal Rai, Rashmi Chourasia, Anirudh K Singh, Shivendra K Chaurasiya

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A Pilot Proteomics Analysis ofInternational journal of molecular sciences · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anjali K Mahato *Molecular Signalling Lab, Department of Biological Sciences and Engineering, Maulana Azad National Institute of Technology, Bhopal, MP, India.
Rupal Rai *Molecular Signalling Lab, Department of Biological Sciences and Engineering, Maulana Azad National Institute of Technology, Bhopal, MP, India.
Rashmi ChourasiaDepartment of Basic Science, IES College of Technology, Bhopal, MP, India.
Anirudh K SinghSchool of Sciences, SAM Global University, Raisen, MP, India.
Shivendra K ChaurasiyaMolecular Signalling Lab, Department of Biological Sciences and Engineering, Maulana Azad National Institute of Technology, Bhopal, MP, India. shivendrachaurasiya@gmail.com.

Funding

ANRF, Startup research grant, India SRG/2023/001498DST-SERB CRG/2020/000520Maulana Azad National Institute of Technology Dean R&C 19/1021 dated 14-08-2019
6 · The paper itself

Abstract

Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), remains a leading global health threat, exacerbated by rising drug resistance and the ability of this pathogen to persist within host macrophages. Central to the intracellular survival of M. tuberculosis is Protein Kinase G (PknG), a secreted, eukaryotic-like serine/threonine kinase that subverts host immune defenses and modulates bacterial physiology. This review provides a comprehensive overview of structural features and the multifaceted role of PknG in M. tuberculosis pathogenesis, including inhibition of phagosome-lysosome fusion, acid tolerance, metabolic reprogramming, autophagy suppression, and cell wall remodelling. Additionally, we discuss recent advancements in targeting PknG with small-molecule inhibitors, highlighting its promise as a therapeutic target. By delineating PknG's central role in host-pathogen interactions and stress adaptation, this review underscores its potential in shaping future anti-TB strategies, especially against drug-tolerant and latent infections..

Indexed as

Bacterial ProteinsCyclic GMP-Dependent Protein KinasesMycobacterium tuberculosisTuberculosisAnimalsAutophagyHost-Pathogen InteractionsHumansMacrophagesProtein Serine-Threonine KinasesBacterial ProteinsCyclic GMP-Dependent Protein Kinasesprotein kinase G, Mycobacterium tuberculosisProtein Serine-Threonine KinasesDrug targetMycobacterium tuberculosisPknGProtein kinaseTB drugs

Identifiers

PMID40434519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.