Evidence map›Paper›PMID 40434517›Full record

ArticleMolecular and cellular biochemistry2025

GPR55 senses lactate to sustain motility in prostate cancer cells.

Giovanna Sgrignani, Marta Iozzo, Lara Di Leonardo, Elisa Pardella, Erica Pranzini, Giulia Gangarossa, Giuseppina Comito, Luigi Ippolito, Elisa Giannoni, Paola Chiarugi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Lactate, a Spearhead of Cancer Aggressiveness: Metabolic Reprogramming, Immune Suppression, and Metastatic Progression.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giovanna Sgrignani *Department of Experimental and Clinical Biomedical Sciences, "Mario Serio". University of Florence, Viale Morgagni 50, 50134, Florence, Italy.
Marta Iozzo *Department of Experimental and Clinical Biomedical Sciences, "Mario Serio". University of Florence, Viale Morgagni 50, 50134, Florence, Italy.
Lara Di LeonardoDepartment of Experimental and Clinical Biomedical Sciences, "Mario Serio". University of Florence, Viale Morgagni 50, 50134, Florence, Italy.
Elisa PardellaDepartment of Experimental and Clinical Biomedical Sciences, "Mario Serio". University of Florence, Viale Morgagni 50, 50134, Florence, Italy.
Erica PranziniDepartment of Experimental and Clinical Biomedical Sciences, "Mario Serio". University of Florence, Viale Morgagni 50, 50134, Florence, Italy.
Giulia GangarossaDepartment of Experimental and Clinical Biomedical Sciences, "Mario Serio". University of Florence, Viale Morgagni 50, 50134, Florence, Italy.
Giuseppina ComitoDepartment of Experimental and Clinical Biomedical Sciences, "Mario Serio". University of Florence, Viale Morgagni 50, 50134, Florence, Italy.
Luigi IppolitoDepartment of Experimental and Clinical Biomedical Sciences, "Mario Serio". University of Florence, Viale Morgagni 50, 50134, Florence, Italy. luigi.ippolito@unifi.it.
Elisa Giannoni *Department of Experimental and Clinical Biomedical Sciences, "Mario Serio". University of Florence, Viale Morgagni 50, 50134, Florence, Italy.
Paola Chiarugi *Department of Experimental and Clinical Biomedical Sciences, "Mario Serio". University of Florence, Viale Morgagni 50, 50134, Florence, Italy.

Funding

Associazione Italiana per la Ricerca sul Cancro 24731Research Projects of Relevant National Interest (PRIN) PRIN2022 Project Code 2022F5JLSE - CUP B53D23021510006
6 · The paper itself

Abstract

The enrichment of specific metabolites within the tumor microenvironment is emerging as a driver of tumor progression. Specifically, in prostate cancer (PCa), increased abundance of lactate is associated with primary-to-metastasis tumor spreading by supporting cancer cell invasiveness. Here, we highlight that the endocannabinoid receptor GPR55 is able to sense lactate and consequently trigger PCa cell amoeboid-like invasiveness, through the activation of the pro-migratory RhoA/MLC2 signaling pathway. These findings uncover a new role for GPR55 in sustaining lactate-driven PCa cell motility.

Indexed as

Cell MovementLactic AcidNeoplasm ProteinsProstatic NeoplasmsReceptors, CannabinoidReceptors, G-Protein-CoupledCell Line, TumorHumansMalerhoA GTP-Binding ProteinSignal TransductionGPR55 protein, humanLactic AcidNeoplasm ProteinsReceptors, CannabinoidReceptors, G-Protein-CoupledrhoA GTP-Binding ProteinAmoeboid motilityGPR55LactateProstate cancer

Identifiers

PMID40434517
PMCPMC12476429

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.