Evidence map›Paper›PMID 40434485›Full record

ArticleHernia : the journal of hernias and abdominal wall surgery2025

Preoperative weight loss for open abdominal wall reconstruction: study protocol for a randomized controlled trial.

Daphne Remulla, Kimberly S Miles, Alvaro Carvalho, Sara M Maskal, W Scott Butsch, Lucas R Beffa, Clayton C Petro, David M Krpata, Ajita S Prabhu, Michael J Rosen and 1 more

Erratum issued Registry-linked trialAbstract readClinical Trial Protocol
PubMed Publisher
In one paragraph

Article in Hernia : the journal of hernias and abdominal wall surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05925959 (Preoperative Weight Loss for Open Abdominal Wall Reconstruction), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05925959 narecruitingnot on this map

Preoperative Weight Loss for Open Abdominal Wall Reconstruction

TypeinterventionalSponsorBenjamin T. MillerRan2023 to 2027Enrolled258ConditionsAbdominal Wall HerniaArmsPreoperative Weight Management Program
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Daphne RemullaDepartment of Surgery, Cleveland Clinic Center for Abdominal Core Health, Cleveland Clinic Foundation, Cleveland, OH, USA. remulld@ccf.org.ORCID 0000-0001-6856-9146
Kimberly S MilesDepartment of Surgery, Cleveland Clinic Center for Abdominal Core Health, Cleveland Clinic Foundation, Cleveland, OH, USA.
Alvaro CarvalhoDepartment of Surgery, Cleveland Clinic Center for Abdominal Core Health, Cleveland Clinic Foundation, Cleveland, OH, USA.
Sara M MaskalDepartment of Surgery, Cleveland Clinic Center for Abdominal Core Health, Cleveland Clinic Foundation, Cleveland, OH, USA.
W Scott ButschDepartment of Surgery, Bariatric and Metabolic Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Lucas R BeffaDepartment of Surgery, Cleveland Clinic Center for Abdominal Core Health, Cleveland Clinic Foundation, Cleveland, OH, USA.
Clayton C PetroDepartment of Surgery, Cleveland Clinic Center for Abdominal Core Health, Cleveland Clinic Foundation, Cleveland, OH, USA.
David M KrpataDepartment of Surgery, Cleveland Clinic Center for Abdominal Core Health, Cleveland Clinic Foundation, Cleveland, OH, USA.
Ajita S PrabhuDepartment of Surgery, Cleveland Clinic Center for Abdominal Core Health, Cleveland Clinic Foundation, Cleveland, OH, USA.
Michael J RosenDepartment of Surgery, Department of Surgery, Northwestern Memorial Hospital, Chicago, IL, USA.
Benjamin T MillerDepartment of Surgery, Cleveland Clinic Center for Abdominal Core Health, Cleveland Clinic Foundation, Cleveland, OH, USA.

Funding

Abdominal Core Health Quality Collaborative AHS 2023 Early Career Development Research Grant
6 · The paper itself

Abstract

backgroundObesity is widely recognized as a risk factor for poor outcomes following ventral hernia repair. This belief has led many surgeons to implement arbitrary body mass index (BMI) cutoffs, typically 35-40 kg/m

methodsThis is a registry-based, parallel, randomized controlled trial with 1:1 allocation. A total of 258 patients with a BMI 40-55 kg/m DISCUSSION: Preoperative weight loss offers potential benefits for patients with obesity undergoing hernia repair including decreased wound morbidity, reduced technical difficulty, and potentially lower recurrence rates. However, disadvantages include prolonged diminished quality of life, risk of emergent hernia repair during the weight loss period, limited access to effective weight loss interventions, and challenges with adherence to weight loss protocols and long-term weight maintenance. This randomized controlled trial will provide high-quality evidence on whether intensive preoperative medical weight loss improves outcomes compared to immediate surgical repair in patients with severe obesity, helping to establish evidence-based guidelines for this challenging patient population.

trial registrationNCT05925959 (registered June 22, 2023).

Indexed as

Hernia, VentralHerniorrhaphyObesityObesity, MorbidPreoperative CareWeight LossWeight Reduction ProgramsAbdominal WallBody Mass IndexHumansQuality of LifeRandomized Controlled Trials as TopicRecurrenceAbdominal wall reconstructionBody mass indexObesityPreoperative weight lossQuality of lifeVentral hernia

Identifiers

PMID40434485

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.