Evidence map›Paper›PMID 40434434›Full record

ReviewMolecular biology reports2025

Molecular basis of autism spectrum disorders.

Raina Desai, Sumanjali Reddy, Michael Truong, Finosh G Thankam

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Raina Desai *Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766-1854, USA.
Sumanjali Reddy *Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766-1854, USA.
Michael TruongDepartment of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766-1854, USA.
Finosh G ThankamDepartment of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766-1854, USA. FThankam@westernu.edu.ORCID http://orcid.org/0000-0001-7285-9808

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism is a prevalent neurological disorder that affects the development of children worldwide. With the advent of genome wide association studies and whole exome sequencing methods, associated genes and molecular pathways that lead to the development of autism spectrum disorder (ASD) have garnered recent attention. However, the etiology of ASD is still rudimentary and poorly understood. Thus, understanding the specific molecular pathways that contribute to autism aids in its clinical diagnosis, management, and treatment. Currently, the genes involved are expansive and affect many molecular pathways. These include transcriptional and translational regulation, proteostasis, cytoskeletal organization, synaptic development and plasticity, and autophagy. Additionally, there are a multitude of factors involved in ASD pathogenesis, including neuroinflammation, signaling defects, and vitamin deficiencies. This review aims to provide a comprehensive understanding regarding the genes and underlying molecular mechanisms that contribute to ASD and the translational therapies for the management of ASD.

Indexed as

Autism Spectrum DisorderAutophagyGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansSignal TransductionASD diagnosisAutism spectrum disorderBehavioral changesMolecular pathwaysNeuroinflammation

Identifiers

PMID40434434
PMCPMC12119779

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.