Evidence map›Paper›PMID 40434428›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Shorter post-infusion cooling times at least as effective as longer cooling times - An observational study of taxane- and anthracycline-based chemotherapies in the Dutch Scalp Cooling Registry.

Florine F I Breed, Wim P M Breed, Marcus W Dercksen, Nicole Ezendam, Maarten J Bijlsma, Corina J G van den Hurk

Abstract readObservational StudyMulticenter Study
PubMed Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Scalp cooling therapy in chemotherapy-induced alopecia: addressing variability in cooling duration and efficacy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Florine F I BreedDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Godebaldkwartier 419, 3511 DT, Utrecht, The Netherlands. florine@grepponblanc.eu.
Wim P M BreedCatharina Hospital, Eindhoven, The Netherlands.
Marcus W DercksenDepartment of Medical Oncology, Máxima Medical Centre, Eindhoven, The Netherlands.
Nicole EzendamDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Godebaldkwartier 419, 3511 DT, Utrecht, The Netherlands.
Maarten J BijlsmaDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Godebaldkwartier 419, 3511 DT, Utrecht, The Netherlands.
Corina J G van den HurkDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Godebaldkwartier 419, 3511 DT, Utrecht, The Netherlands. corina.vd.hurk@catharinaziekenhuis.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChemotherapy-induced alopecia (CIA), a very common and distressing side effect of cancer treatment can be effectively prevented by scalp cooling. The aim of this observational study was to estimate the effect of post-infusion cooling time (PICT) on wearing a head cover for taxane- and anthracycline-based chemotherapies.

methodsThe Dutch Scalp Cooling Registry (DSCR), which started in January 2006, collected data from 4680 scalp-cooled patients across 68 Dutch hospitals. Questionnaires on patient, chemotherapy and scalp cooling characteristics were completed by patients and nurses. The patient-reported primary outcome included the use of head covering during the final scalp cooling session. Analysis included patients who had received Docetaxel 75 or 100 mg/m

resultsShorter post-infusion cooling times (< 85 minutes) seem to be sufficient for maintaining scalp cooling effectiveness in the chemotherapy regimens studied, with no added benefit from extending cooling time beyond this threshold.

conclusionFor all anthracycline and taxane-based chemotherapy regimens studied, shorter PICTs delivered comparable results to longer PICTs.

Indexed as

AlopeciaAntineoplastic Combined Chemotherapy ProtocolsHypothermia, InducedAdultAgedAnthracyclinesFemaleHumansMaleMiddle AgedNeoplasmsNetherlandsRegistriesScalpSurveys and QuestionnairesTaxoidsAnthracyclinesTaxoidsAnthracyclineChemotherapy-induced alopeciaHair lossPost-infusion cooling timeScalp coolingTaxane

Identifiers

PMID40434428

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.