Evidence map›Paper›PMID 40434424›Full record

ArticleArchives of toxicology2025

Neurodevelopmental toxicity and mechanism of chlorinated polyfluoroalkyl ether sulfonate alternative F-53B in pubertal male rats.

Lu Sun, Yao Chen, Junyan Chen, Guanghua Mao, Weiwei Feng, Xiangyang Wu

Abstract read
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In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lu SunSchool of the Environment and Safety, School of Emergency Management, Key Laboratory of Zhenjiang Jiangsu University, 301 Xuefu Rd., Zhenjiang, 212013, Jiangsu, China.
Yao ChenSchool of the Environment and Safety, School of Emergency Management, Key Laboratory of Zhenjiang Jiangsu University, 301 Xuefu Rd., Zhenjiang, 212013, Jiangsu, China. chenyao1390@ujs.edu.cn.ORCID 0009-0005-8910-3229
Junyan ChenSchool of the Environment and Safety, School of Emergency Management, Key Laboratory of Zhenjiang Jiangsu University, 301 Xuefu Rd., Zhenjiang, 212013, Jiangsu, China.
Guanghua MaoSchool of the Environment and Safety, School of Emergency Management, Key Laboratory of Zhenjiang Jiangsu University, 301 Xuefu Rd., Zhenjiang, 212013, Jiangsu, China.
Weiwei FengSchool of the Environment and Safety, School of Emergency Management, Key Laboratory of Zhenjiang Jiangsu University, 301 Xuefu Rd., Zhenjiang, 212013, Jiangsu, China.
Xiangyang WuSchool of the Environment and Safety, School of Emergency Management, Key Laboratory of Zhenjiang Jiangsu University, 301 Xuefu Rd., Zhenjiang, 212013, Jiangsu, China.

Funding

Drug Efficacy and Health Risk Assessment Key Laboratory of Zhenjiang SS2024006Natural Science Foundation of Jiangsu Province BK20200917
6 · The paper itself

Abstract

F-53B, a substitute for perfluorooctane sulfonate (PFOS), has attracted considerable concerns due to its frequent detection in environment matrices. However, the potential health risks to mammals, especially neurodevelopmental toxicity, remain unclear. In this study, 3-week-old pubertal male rats were exposed to F-53B at concentrations of 0, 0.15, 1.5, and 15 μg/kg for 3 weeks continuously. Diminished cognitive abilities were observed by morris water maze (MWM) test, F-53B exposure increased the escape latency and decreased the time spent in the target quadrant of rats. Furthermore, F-53B significantly altered neurotransmitter levels in the hippocampus. Molecular docking studies indicated that F-53B might bind to metabotropic glutamate receptor 5 (mGluR5), potentially entering neurons and causing further neurotoxicity. qRT-PCR and western blot analyses were used to assess the expression of genes and proteins related to calcium pathways. Results revealed that F-53B exposure downregulated mRNA expression of ryanodine receptors (RyRs) and the phosphorylation of inositol trisphosphate receptors (IP3Rs), while upregulating sarco/endoplasmic reticulum Ca

Indexed as

Alkanesulfonic AcidsEnvironmental PollutantsFluorocarbonsAnimalsHippocampusMaleMolecular Docking SimulationRatsRats, Sprague-DawleyReceptor, Metabotropic Glutamate 5Ryanodine Receptor Calcium Release ChannelSarcoplasmic Reticulum Calcium-Transporting ATPasesAlkanesulfonic AcidsEnvironmental PollutantsFluorocarbonsGrm5 protein, ratReceptor, Metabotropic Glutamate 5Ryanodine Receptor Calcium Release ChannelSarcoplasmic Reticulum Calcium-Transporting ATPasesCalcium signaling pathwayF-53BLearning and memoryMechanismNeurodevelopmental toxicity

Identifiers

PMID40434424

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.