Evidence map›Paper›PMID 40434402›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2025

Spatiotemporal calcium signaling patterns underlying opposing effects of histamine and TAS2R agonists in airway smooth muscle.

Stanley Conaway, Joshua Richard, Deepak A Deshpande

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Spatiotemporal calcium signaling to unlock the calcium paradox: location, location, location!American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Stanley ConawayCenter for Translational Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Jane & Leonard Korman Respiratory Institute, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States.ORCID 0000-0003-4855-6588
Joshua RichardCenter for Translational Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Jane & Leonard Korman Respiratory Institute, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States.
Deepak A DeshpandeCenter for Translational Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Jane & Leonard Korman Respiratory Institute, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States.ORCID 0000-0002-6187-5332

Funding

Diacylglycerol kinase in airway smooth muscle functionsR01HL146645 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI DESHPANDE, DEEPAK A, KAMBAYASHI, TAKU · 2019 to 2024
$2.8M
tRNA-derived non-coding RNAs in ASM function and in asthmaR01HL150560 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI DESHPANDE, DEEPAK A, KIRINO, YOHEI · 2020 to 2023
$2.4M
Functional Diversity of Compartmentalized Calcium Signaling in Airway Smooth MuscleR01HL137030 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI DESHPANDE, DEEPAK A · 2018 to 2021
$2.2M
Allosteric modulation of beta2- adrenoceptors in the treatment of asthmaR01HL173113 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI Deepak A Deshpande · 2024 to 2026
$1.7M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL137030HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL137030-S1HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL146645NHLBI NIH HHS R01 HL137030NHLBI NIH HHS R01 HL146645NHLBI NIH HHS R01 HL150560NHLBI NIH HHS R01 HL173113
6 · The paper itself

Abstract

Intracellular calcium (Ca

Indexed as

Calcium SignalingHistamineMuscle, SmoothReceptors, G-Protein-CoupledAnimalsCalciumChloroquineFlufenamic AcidHumansMyocytes, Smooth MuscleRespiratory SystemTaste Receptors, Type 2CalciumChloroquineFlufenamic AcidHistamineReceptors, G-Protein-CoupledTaste Receptors, Type 2airway smooth musclecalciumchloroquineTAS2R

Identifiers

PMID40434402
PMCPMC12188627

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.