ReviewThe oncologist2025
Current landscape in first-line treatment of metastatic hormone sensitive prostate cancer: a cost-effectiveness focused review.
Review in The oncologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Literature Review on Economic Evaluations and Health Economic Models in Metastatic Castration-Sensitive Prostate Cancer.Current oncology (Toronto, Ont.) · 2025Pooled it
- VprBP drives prostate tumorigenesis by its kinase activity targeting histone H2A.Cell communication and signaling : CCS · 2026Article
- Review
- Uncertain magnitude of benefit of early second-generation androgen receptor antagonist treatment in advanced prostate cancer.Oncology reviews · 2026Review
- Advancing 3D scaffold models for metastatic prostate cancer in bone: Materials, manufacture, and future perspectives.Biomaterials and biosystems · 2025Review
- Direct and Indirect Costs of Prostate Cancer: A Comprehensive Assessment of Economic and Social Impact.Cancers · 2025Article
- Cost-effectiveness analysis of eight first-line treatments for metastatic hormone-sensitive prostate cancer in China.Frontiers in pharmacology · 2025Article
- Real-world Treatment Selection and Shared Decision-making in De Novo Metastatic Castration-sensitive Prostate Cancer in Japan.Cancer diagnosis & prognosisArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Contemporary treatment of metastatic hormone-sensitive prostate cancer (mHSPC) has evolved significantly over the past decade with the introduction of upfront combination therapies (ie, ADT plus androgen receptor pathway inhibitors (ARPIs), with or without docetaxel), previously reserved for more advanced stages of the disease. However, the evidence is still controversial regarding the benefit of triple combinations beyond high volume disease (HVD) compared to double combinations, particularly those consisting of ADT + ARPIs. In addition, financial considerations regarding net benefits make these treatment regimens an unfavorable option from a cost-effectiveness standpoint, an element that becomes even more relevant in resource-limited contexts. Considering the lack of head-to-head trials for the direct comparison of triplets vs. ADT + ARPIs in different subgroups (as most evidence of specific combination superiority comes from indirect comparison in meta-analyses and the questionable cost-effectiveness profile triplets have shown), we propose that the current role of triplets is reserved for synchronous, HVD mHSPC in a resource-rich setting. Consequently, our work proposes a treatment algorithm that weighs the OS benefit according to the clinical risk of each patient subgroup and the availability of clinical resources. In this current scenario of abundant options, future research will focus on clarifying the selection of the most appropriate treatment for each patient according to their clinical characteristics and re-evaluating the cost-effectiveness of treatments as new drugs and generics emerge.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.