Evidence map›Paper›PMID 40434211›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2025

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials.

Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Engineering Silk Fibroin-Based Biomaterials for Neural Repair.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  7. Review
  8. Piezo channels in tumors.Journal of cancer research and clinical oncology · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Mechanomedicine.Nature reviews bioengineering · 2026
    Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xinyu WangNational Center for Orthopaedics, Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200233, Shanghai, China.ORCID https://orcid.org/0000-0003-3744-7255
Sílvio Terra StefanelloInstitute of Physiology II, University of Münster, Robert-Koch-Str. 27b, 48149, Münster, Germany.ORCID https://orcid.org/0000-0002-6673-6550
Victor ShahinInstitute of Physiology II, University of Münster, Robert-Koch-Str. 27b, 48149, Münster, Germany.ORCID https://orcid.org/0000-0003-2710-6473
Yun QianNational Center for Orthopaedics, Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200233, Shanghai, China.ORCID https://orcid.org/0000-0003-1600-5693

Funding

Chinesisch-Deutsche Zentrum für Wissenschaftsförderung M-0699Excellent Youth Cultivation Program of Shanghai Sixth People's Hospital ynyq202201National Key R&D Program of China 2021YFC2400800National Natural Science Foundation of China 82372409Sino-German Mobility Programme M-0699
6 · The paper itself

Abstract

Piezoelectric materials, capable of converting mechanical stimuli into electrical signals, have emerged as promising tools in regenerative medicine due to their potential to stimulate tissue repair. Despite a surge in research on piezoelectric biomaterials, systematic insights to direct their translational optimization remain limited. This review addresses the current landscape by bridging fundamental principles with clinical potential. The biomimetic basis of piezoelectricity, key molecular pathways involved in the synergy between mechanical and electrical stimulation for enhanced tissue regeneration, and critical considerations for material optimization, structural design, and biosafety is discussed. More importantly, the current status and translational quagmire of mechanisms and applications in recent years are explored. A mechanism-driven strategy is proposed for the therapeutic application of piezoelectric biomaterials for tissue repair and identify future directions for accelerated clinical applications.

Indexed as

Biocompatible MaterialsMechanical PhenomenaRegenerationAnimalsHumansRegenerative MedicineTissue EngineeringBiocompatible Materialsadvanced materials for translational medicinebiosensorspiezoelectricityregenerative medicinetissue engineering

Identifiers

PMID40434211
PMCPMC12369703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.