Evidence map›Paper›PMID 40434128›Full record

ArticleMicrobiology spectrum2025

Mechanistic divergence between SOS response activation and antibiotic-induced plasmid conjugation in

Ruoxuan Zhao, Arkadiusz Nawrocki, Jakob Møller-Jensen, Gang Liu, John Elmerdahl Olsen, Line Elnif Thomsen

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ruoxuan ZhaoDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.
Arkadiusz NawrockiDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Region Syddanmark, Denmark.
Jakob Møller-JensenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Region Syddanmark, Denmark.
Gang LiuDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.
John Elmerdahl OlsenDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.ORCID 0000-0001-6225-6587
Line Elnif ThomsenDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.ORCID 0000-0001-5460-9178

Funding

China Scholarship Council
6 · The paper itself

Abstract

The SOS response is a critical DNA damage repair mechanism in bacteria, designed to counteract genotoxic stress and ensure survival. This system can be activated by different classes of antimicrobial agents, each inducing the SOS response through different mechanisms. Moreover, it has been observed that certain antibiotics can enhance conjugative plasmid transfer frequencies. However, while previous studies have suggested that the SOS response contributes to horizontal transfer of certain genes, its role in plasmid conjugation remains unclear. In this study, we investigated the relationship between the SOS response and conjugation of IncI1 and IncFII plasmids harboring various

Indexed as

Anti-Bacterial AgentsConjugation, GeneticEscherichia coliPlasmidsSOS Response, GeneticsCefotaximeCiprofloxacinEscherichia coli ProteinsGene Expression Regulation, BacterialGene Transfer, HorizontalMitomycinAnti-Bacterial AgentsCefotaximeCiprofloxacinEscherichia coli ProteinsMitomycinantibioticsconjugationEscherichia coliIncI1SOS response

Identifiers

PMID40434128
PMCPMC12211044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.