Evidence map›Paper›PMID 40434069›Full record

ArticlemSystems2025

Phage DisCo: targeted discovery of bacteriophages by co-culture.

Eleanor A Rand, Natalia Quinones-Olvera, Kesther D C Jean, Carmen Hernandez-Perez, Siân V Owen, Michael Baym

Abstract read
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eleanor A RandDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-0775-2064
Natalia Quinones-OlveraDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA.
Kesther D C JeanDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA.
Carmen Hernandez-PerezDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA.
Siân V OwenDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-5330-3177
Michael BaymDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-1303-5598

Funding

Evolutionary Tradeoffs in Antibiotic ResistanceR35GM133700 · NIGMS · HARVARD MEDICAL SCHOOL · PI BAYM, MICHAEL · 2019 to 2023
$2.4M
Harvard Systems Biology Graduate ProgramT32GM135014 · NIGMS · HARVARD UNIVERSITY · PI DESAI, MICHAEL M, KLEIN, ALLON MOSHE · 2020 to 2024
$1.6M
Evolutionary Tradeoffs in Antibiotic ResistanceR35GM156320 · NIGMS · HARVARD MEDICAL SCHOOL · PI Michael Baym · 2025 to 2026
$967k
Receptor-Guided Discovery of Environmental PhagesF31AI178993 · NIAID · HARVARD UNIVERSITY · PI RAND, ELEANOR · 2024 to 2025
$44k
David and Lucile Packard Foundation Packard FellowshipNational Institute of Allergy and Infectious Diseases F31AI178993National Science Foundation IOS-2331228NIAID NIH HHS F31 AI178993NIGMS NIH HHS R35 GM133700NIGMS NIH HHS R35GM133700, R35GM156320, T32GM135014NIGMS NIH HHS R35 GM156320NIGMS NIH HHS T32 GM135014Pew Charitable Trusts Pew Biomedical Scholarship
6 · The paper itself

Abstract

Phages interact with many components of bacterial physiology from the surface to the cytoplasm. Although there are methods to determine the receptors and intracellular systems a specified phage interacts with retroactively, finding a phage that interacts with a chosen piece of bacterial physiology

Indexed as

BacteriophagesCoculture TechniquesViral Plaque Assaybacteriophagesbacteriophage therapyphage defensephage receptor

Identifiers

PMID40434069
PMCPMC12172434

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.