Evidence map›Paper›PMID 40434063›Full record

ArticleACS nano2025

Outer Membrane Vesicles from

Luis David Ginez, Aurora Osorio, Víctor Correal-Medina, Thelma Arenas, Claudia González-Espinosa, Laura Camarena, Sebastian Poggio

Erratum issuedAbstract read
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Luis David GinezDepartamento de Biología Molecular y Biotecnologia, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Circuito Mario de la Cueva s/n, Ciudad Universitaria, Ciudad de México 04510, México.
Aurora OsorioDepartamento de Biología Molecular y Biotecnologia, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Circuito Mario de la Cueva s/n, Ciudad Universitaria, Ciudad de México 04510, México.
Víctor Correal-MedinaDepartamento de Biología Molecular y Biotecnologia, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Circuito Mario de la Cueva s/n, Ciudad Universitaria, Ciudad de México 04510, México.
Thelma ArenasDepartamento de Biología Molecular y Biotecnologia, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Circuito Mario de la Cueva s/n, Ciudad Universitaria, Ciudad de México 04510, México.
Claudia González-EspinosaPharmacobiology Department and Center for Research in Aging, Center for Research and Advanced Studies (Cinvestav), South Campus, Calzada de los Tenorios No. 235, Col. Granjas Coapa, Alcaldía Tlalpan, Ciudad de México 14330, México.
Laura CamarenaDepartamento de Biología Molecular y Biotecnologia, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Circuito Mario de la Cueva s/n, Ciudad Universitaria, Ciudad de México 04510, México.
Sebastian PoggioDepartamento de Biología Molecular y Biotecnologia, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Circuito Mario de la Cueva s/n, Ciudad Universitaria, Ciudad de México 04510, México.ORCID 0000-0001-9494-3365

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial outer membrane vesicles (OMVs) are an emerging and attractive technology for the generation of vaccines. Their properties as natural adjuvants, size, acellularity, and comparative cost of production favor their use as vaccines. Two major caveats for the use of OMVs as vaccines are their biological safety, since OMVs can induce a severe and even fatal inflammatory response and that they are naturally produced in low amounts. In this study, we show that a strategy to induce the production of OMVs applied to the nonpathogenic bacterium

Indexed as

Bacterial Outer MembraneBacterial Outer Membrane ProteinsCaulobacter crescentusRecombinant ProteinsAnimalsBacterial VaccinesFemaleHumansMiceBacterial Outer Membrane ProteinsBacterial VaccinesRecombinant ProteinsCaulobacter crescentusinflammatory cytokineslipid AOmpAouter membrane vesiclesS-layervaccine platform

Identifiers

PMID40434063
PMCPMC12164514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.