Evidence map›Paper›PMID 40433992›Full record

ArticleEpidemiology (Cambridge, Mass.)2025

Medium-term Exposure to Wildfire Smoke PM 2.5 and Cardiorespiratory Hospitalization Risks.

Yaguang Wei, Edgar Castro, Kanhua Yin, Alexandra Shtein, Bryan N Vu, Mahdieh Danesh Yazdi, Longxiang Li, Yuxi Liu, Adjani A Peralta, Joel D Schwartz

Abstract read
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yaguang WeiFrom the Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-6796-7510
Edgar CastroDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Kanhua YinDepartment of Surgery, University of Missouri-Kansas City School of Medicine, Kansas City, MO.
Alexandra ShteinDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Bryan N VuDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Mahdieh Danesh YazdiDepartment of Family, Population, and Preventive Medicine, Program in Public Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY.
Longxiang LiGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA.
Yuxi LiuDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Adjani A PeraltaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Joel D SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Identifying low dose measurement error corrected effects of multiple pollutants using causal modelingR01ES032418 · NIEHS · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI SCHWARTZ, JOEL D · 2021 to 2024
$1.7M
Population-Based Assessment of the Health Effects of Climate Exposure Using Hyperlocal Predictive ModelsR01ES036566 · NIEHS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Mahdieh Danesh Yazdi · 2024 to 2026
$972k
NCATS NIH HHS UL1 TR004419NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES032418NIEHS NIH HHS R01 ES036566
6 · The paper itself

Abstract

backgroundWildfire activity in the United States has increased substantially in recent decades. Smoke fine particulate matter (PM 2.5 ), a primary wildfire emission, can remain in the air for months after a wildfire begins, yet large-scale evidence of its health effects remains limited.

methodsWe obtained hospitalization records for the residents of 15 states between 2006 and 2016 from the State Inpatient Databases. We used existing daily smoke PM 2.5 estimations at 10-km 2 grid cells across the contiguous United States and aggregated them to ZIP codes to match the spatial resolution of hospitalization records. We extended the traditional case-crossover design, a self-controlled design originally developed for studying acute effects, to examine associations between 3-month average exposure to smoke PM 2.5 and hospitalization risks for a comprehensive range of cardiovascular (ischemic heart disease, cerebrovascular disease, heart failure, arrhythmia, hypertension, and other cardiovascular diseases) and respiratory diseases (acute respiratory infections, pneumonia, chronic obstructive pulmonary disease, asthma, and other respiratory diseases).

resultsWe found that 3-month exposure to smoke PM 2.5 was associated or marginally associated with increased hospitalization risks for most cardiorespiratory diseases. Hypertension showed the greatest susceptibility, with the highest hospitalization risk associated with 0.1 µg/m 3 increase in 3-month smoke PM 2.5 exposure (relative risk: 1.0051; 95% confidence interval = 1.0035, 1.0067). Results for single-month lagged exposures suggested that estimated effects persisted up to 3 months after exposure. Subgroup analyses estimated larger effects in neighborhoods with higher deprivation level or more vegetation, as well as among ever-smokers.

conclusionsOur findings provided unique insights into medium-term cardiorespiratory effects of smoke PM 2.5 , which can persist for months, even after a wildfire has ended.

Indexed as

Air PollutantsCardiovascular DiseasesEnvironmental ExposureHospitalizationParticulate MatterRespiratory Tract DiseasesSmokeWildfiresAdultAgedFemaleHumansMaleMiddle AgedUnited StatesAir PollutantsParticulate MatterSmokeCardiorespiratory diseasesMedium-term effectSelf-controlled designWildfire

Identifiers

PMID40433992
PMCPMC12234148

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.