Evidence map›Paper›PMID 40433952›Full record

ArticleeLife2025

Structural mechanisms of PIP

Jing Xue, Weizhong Zeng, Scott John, Nicole Attiq, Michela Ottolia, Youxing Jiang

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jing XueDepartment of Physiology, The University of Texas Southwestern Medical Center, Dallas, United States.ORCID https://orcid.org/0000-0002-7331-1382
Weizhong ZengDepartment of Physiology, The University of Texas Southwestern Medical Center, Dallas, United States.
Scott JohnDepartment of Medicine (Cardiology), UCLA, Los Angeles, United States.ORCID https://orcid.org/0000-0002-1232-9140
Nicole AttiqDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, United States.
Michela OttoliaDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, United States.ORCID https://orcid.org/0000-0002-5114-8887
Youxing JiangDepartment of Physiology, The University of Texas Southwestern Medical Center, Dallas, United States.ORCID https://orcid.org/0000-0002-1874-0504

Funding

Sodium Dependent Inactivation of the Na+-Ca2+ exchange: Relevance to Cardiac FunctionR01HL152296 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLCESE, RICCARDO, OTTOLIA, MICHELA · 2021 to 2024
$2.2M
Structural and Functional Studies of Organellar Ion ChannelsR35GM140892 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, YOUXING · 2021 to 2025
$1.6M
NHLBI NIH HHS R01 HL152296NIGMS NIH HHS R35 GM140892NIGMS NIH HHS R35GM140892NIH HHS R01HL152296Welch Foundation I-1578
6 · The paper itself

Abstract

Na

Indexed as

Phenyl EthersPhosphatidylinositol 4,5-DiphosphateSodium-Calcium ExchangerAniline CompoundsCalciumCryoelectron MicroscopyHumansModels, MolecularProtein BindingProtein ConformationAniline CompoundsCalciumPhenyl EthersPhosphatidylinositol 4,5-DiphosphateSEA 0400Sodium-Calcium Exchangersodium-calcium exchanger 1cardiac sodium-calcium exchangerhumanmolecular biophysicsPIP2 activationSEA0400 inhibitionstructural biology

Identifiers

PMID40433952
PMCPMC12119087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.