Evidence map›Paper›PMID 40433903›Full record

ArticleACS applied materials & interfaces2025

3D-Printed Cellulose Aerogels Minimally Cross-Linked with Polyurea: A Robust Strategy for Tissue Engineering.

Ana Iglesias-Mejuto, Grigorios Raptopoulos, Nanthilde Malandain, Mariana Neves Amaral, Inés Ardao, Matjaž Finšgar, Anna Laromaine, Anna Roig, Catarina Pinto Reis, Carlos A García-González and 1 more

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Role of cellulose and its derivatives for 3D printing of bone tissue scaffolds.Frontiers in bioengineering and biotechnology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ana Iglesias-MejutoAerogelsLab, I+D Farma Group (GI-1645), Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, iMATUS and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de CompostelaE-15782, Spain.
Grigorios RaptopoulosInorganic Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens15771, Greece.
Nanthilde MalandainInstitut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, Bellaterra08193, Spain.ORCID 0000-0001-6447-2726
Mariana Neves AmaralResearch Institute for Medicines (iMed. ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Professor Gama Pinto, Lisboa1649-003, Portugal.
Inés ArdaoBioFarma Research Group, Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Innopharma Drug Screening and Pharmacogenomics Platform, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela15782, Spain.
Matjaž FinšgarFaculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, MariborSI-2000, Slovenia.ORCID 0000-0002-8302-9284
Anna LaromaineInstitut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, Bellaterra08193, Spain.ORCID 0000-0002-4764-0780
Anna RoigInstitut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, Bellaterra08193, Spain.ORCID 0000-0001-6464-7573
Catarina Pinto ReisResearch Institute for Medicines (iMed. ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Professor Gama Pinto, Lisboa1649-003, Portugal.
Carlos A García-GonzálezAerogelsLab, I+D Farma Group (GI-1645), Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, iMATUS and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de CompostelaE-15782, Spain.ORCID 0000-0001-9542-3679
Patrina ParaskevopoulouInorganic Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens15771, Greece.ORCID 0000-0002-5166-8946

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellulose and its derivatives are increasingly explored in biomedical applications due to their biocompatibility, biodegradability, and mechanical performance. In regenerative medicine, aerogel scaffolds with tunable morphology and composition are highly valued for their ability to support tissue regeneration. Three-dimensional (3D) printing offers an effective method to fabricate aerogels with hierarchical pore structures, comprising interconnected macropores and mesopores, that are crucial for tissue engineering. For clinical use, 3D printing should ensure the structural integrity of printed structures and achieve a printing resolution that allows for customization. In this work, the X-aerogel technology, implemented via polyurea cross-linking, was applied to 3D-printed cellulose structures, thereby expanding the potential applications of both technologies. Specifically, 3D-printed methylcellulose (MC) and MC doped with bacterial cellulose nanofiber (MCBCf) gels were cross-linked with an aliphatic polyurea, yielding, after supercritical drying, the corresponding (X-MC and X-MCBCf) aerogels. Elaborate characterization with ATR-FTIR, XPS, ToF-SIMS, N

Indexed as

Biocompatible MaterialsCellulosePolymersPrinting, Three-DimensionalTissue EngineeringAnimalsCross-Linking ReagentsGelsHumansPorosityTissue ScaffoldsBiocompatible MaterialsCelluloseCross-Linking ReagentsGelsPolymerspolyurea3D printingaerogelscellulosemethylcellulosepolyureatissue engineeringX-aerogels

Identifiers

PMID40433903
PMCPMC12163874

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.