ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Glucose-Responsive and Analgesic Gel for Diabetic Subcutaneous Abscess Treatment by Simultaneously Boosting Photodynamic Therapy and Relieving Hypoxia.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A recent review on smart dressings for chronic wound management: from diagnosis to therapy.RSC advances · 2026Review
- A Binary Natural Herbal Co-Assembled Hydrogel for Expediting MRSA-Infected Diabetic Wound Healing via Robust Sterilization, Anti-Inflammation and Tissue Repair.Advanced healthcare materials · 2026Article
- Confined coordination regulation of rhodium in organosilica active framework for enhanced photothermal-enzymatic diabetic wound healing.Materials today. Bio · 2026Article
- A Multifunctional ε-Polylysine/Hyaluronic Acid Hydrogel Promotes Diabetic Wound Healing by Orchestrating Multidimensional Synergy.Pharmaceutics · 2026Article
- Exploring Compositions of Cell-Based Therapies for Diabetic Foot Ulcer Treatment: A Review of Clinical Studies.Stem cell reviews and reports · 2026Review
- Stimuli-responsive hydrogels based on cascade reactions: a novel strategy to promote the efficient repair of diabetic wounds.Theranostics · 2026Review
- Three-dimensional bioprinted hydrogels for the management of diabetic wounds: A review.BioImpacts : BI · 2026Review
- Photodynamic Strategies for Prevention of Titanium Osteoimplant Infections.Research (Washington, D.C.) · 2026Review
- Lactose-conjugated 2-iminothiazolidin-4-ones: synthesis, inhibitory activity and molecular simulations as potential inhibitors against enzymes responsible for type 2 diabetes.RSC medicinal chemistry · 2025Article
- Repurposing DPP-4 inhibitors as anticancer agents in KRAS-mutated pancreatic ductal adenocarcinoma.BMC pharmacology & toxicology · 2025Article
- Zinc-Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post-Pancreatectomy Cutaneous Wound Healing.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Personalized Nutrition in the Era of Digital Health: A New Frontier for Managing Diabetes and Obesity.Food science & nutrition · 2025Review
- Pan-cancer analysis of PTPN6: prognostic significance and functional implications in tumor progression.Discover oncology · 2025Article
- Comparative Pharmacological and Pharmaceutical Perspectives on Antidiabetic Therapies in Humans, Dogs, and Cats.Pharmaceutics · 2025Review
- Glucose-Responsive and Analgesic Gel for Diabetic Subcutaneous Abscess Treatment by Simultaneously Boosting Photodynamic Therapy and Relieving Hypoxia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Synthesis, crystal structure, andFuture medicinal chemistry · 2025Article
- Targeting the molecular crosstalk between diabetes and lung cancer for therapeutic intervention.Discover oncology · 2025Review
- From Ulcer to Amputation: A Systematic Review of Prognostic Models for Diabetic Foot Ulcer Amputation.Risk management and healthcare policy · 2025Review
- Association of serum creatinine/cystatin C ratio with insulin resistance and all-cause mortality: a national cohort analysis.Frontiers in nutrition · 2025Article
- Therapeutic efficacy and mechanisms of gentiopicroside in various diseases.Frontiers in pharmacology · 2025Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
The treatment of diabetic abscess remains highly challenging due to the complex wound healing environment, which includes bacterial infection, hypoxia, and pain, severely compromising patients' quality of life. Developing effective treatment strategies to address these multifaceted issues continues to pose significant challenges. In this study, a glucose-triggered gel with self-producing oxygen, photodynamic behavior, and analgesic properties is employed to address the aforementioned problems. The gel utilizes the cascade reaction of glucose oxidase and catalase to convert the excessive glucose in diabetic abscess tissue into oxygen, alleviate the hypoxia in the infected tissue, and ensure the occurrence of hypoxia photodynamic behavior to generate sufficient reactive oxygen species (ROS) to combat pathogenic bacteria. Simultaneously, borneol within the gel can not only enhance the sensitivity of bacteria to ROS by regulating the oxidative stress system but also augment the antibacterial effect of ROS. Moreover, borneol can serve as an analgesic to alleviate pain in patients. In vivo experiments have demonstrated that the combination of photodynamic and borneol therapy can eliminate the bacteria at the abscess site and enable the abscess to heal completely within 12 days. Therefore, this study established a glucose-responsive gel for a combined therapy strategy of hypoxic improvement photodynamic therapy and borneol to facilitate wound healing in diabetic abscesses.
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