SynthesisEuropean psychiatry : the journal of the Association of European Psychiatrists2025
Association between adverse childhood experiences and suicidal behavior in affective disorders: A systematic review and meta-analysis.
Synthesis in European psychiatry : the journal of the Association of European Psychiatrists, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Psychological factors mediating/moderating the association between adverse childhood experiences and suicidal ideation in young people: a systematic review.European child & adolescent psychiatry · 2026Pooled it
- Oxytocin dysfunction in severe mental illnesses following adverse childhood experiences: a systematic review.BMC psychiatry · 2026Pooled it
- Intimate partner violence and mental disorders among women: an umbrella review.BMC psychiatry · 2025Pooled it
- Structural equation modeling of the effect of childhood trauma on premenstrual syndrome: the mediating role of rumination in adolescent girls.Scientific reports · 2026Article
- Adversity as the key feature: neuroimaging profiles of subtypes from multiple depression risk factors.Psychological medicine · 2026Article
- Psychological flexibility as a mediating mechanism linking adverse and positive childhood experiences to suicidal thoughts in emerging adults.BMC pediatrics · 2026Article
- Adverse childhood experiences, depressive symptoms, and non-suicidal self-injury in Chinese adolescents: the moderating role of SKA2 gene rs7208505 polymorphism.Behavioral and brain functions : BBF · 2026Article
- Different types of childhood trauma in relation to borderline personality traits and self-control in Chinese adolescents.BMC psychiatry · 2026Article
- The specific mediating role of social anhedonia in the relationship between childhood emotional abuse and depressive symptoms in bipolar disorder.BMC psychiatry · 2026Article
- Mediation role of artificial intelligence exposure in adverse childhood experiences: related mental health risks among college students.Scientific reports · 2026Article
- Associations between childhood trauma, emotional regulation, and self-esteem in predicting suicidal behaviour among adolescents in secondary schools in Lagos, Nigeria (SPREAD STUDY).BMC psychiatry · 2026Article
- European Psychiatry: 2025 in review.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Childhood trauma and suicidal behavior risk: perceived burdensomeness and negative emotional reactivity in a cross-sectional study.Frontiers in psychology · 2026Article
- Impact of childhood trauma on depressive symptoms in bipolar adolescents: the mediating effect of sleep disturbance.BMC psychiatry · 2025Article
- Dysfunctional attitude and childhood maltreatment predict future recurrence among young adults with first-onset depression: a prospective cohort study.BMC psychiatry · 2025Article
- Silent struggles: a machine learning approach for predicting suicidal ideation based on crisis symptoms and childhood trauma in Saudi adolescents.BMC psychology · 2025Article
- Adverse childhood experiences and hearing loss: the mediating role of sleep disorders in a Chinese cohort.BMC psychiatry · 2025Article
- Biological rhythm and depression severity mediate the relationship between adverse childhood experiences and non-suicidal self-injury among adolescents with depressive disorder.Scientific reports · 2025Article
- Trauma exposure among individuals with mood disorders: a cross-sectional study at a tertiary psychiatric facility in Uganda.BMC psychiatry · 2025Article
- Gender-differentiated pathways from childhood trauma to self-injury: rumination as a mediator in depressed adolescents.BMC psychology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
backgroundExposure to Adverse Childhood Experiences (ACEs) might increase the risk of suicide behaviors in the general adult population, while this association in individuals with affective disorders remains less characterized.
methodsA comprehensive search was conducted in MEDLINE, PsycINFO, CINAHL, Web of Science, Scopus, and PubMed up to July 10th, 2024. Observational studies that compared the risk of suicide behaviors in individuals exposed and unexposed to ACEs were included. Pairwise random-effects meta-analyses were conducted, and the certainty of evidence was assessed with validated criteria.
resultsA total of 41 studies from 17 countries, comprising 19,588 participants, were analyzed. The main findings indicated a significant association between ACEs and suicidal behaviors, with an odds ratio (OR) of 1.98 (95% confidence interval [CI] 1.74-2.26), and a "highly suggestive" strength of association. This was consistent across diagnostic subgroups (i.e., Major Depressive Disorders, Bipolar Disorders, and mixed diagnoses). The association was confirmed for any ACE, with sexual abuse being the most frequently reported and showing the highest risk (OR 2.24; 95% CI 1.90-2.64), for suicidal ideation (OR 2.16; 95% CI 1.42-3.29), and for suicide attempts (OR 1.95; 95% CI 1.70-2.25), while death by suicide and non-suicidal self-injury were underreported. Meta-regression analyses did not suggest potential moderators, though underreporting was noted.
conclusionsThis meta-analysis shows that exposure to ACEs nearly doubles the risk of suicide behaviors in individuals with affective disorders, warranting the targeted clinical, research, and policy measures to timely address this global mental health issue.
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