ArticleJournal of cosmetic dermatology2025
Therapeutic Modulation of Demodex Density via Isotretinoin: Insights From a Prospective Dermatological Investigation.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- The exposomal imprint on rosacea: More than skin deep.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Review
- Sebum-Selective 1,726-nm Laser Therapy for Papulopustular Rosacea Associated withClinical, cosmetic and investigational dermatology · 2026Article
- Reducing ocularFrontiers in allergy · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimDemodex spp. are ectoparasites that reside in pilosebaceous units, particularly on the face where sebum secretion is prominent. The sebum-reducing effects of isotretinoin play a crucial role in the management of acne vulgaris and rosacea. This study aims to assess the effect of isotretinoin on Demodex density in patients with acne vulgaris and rosacea accompanied by demodicosis. The evaluation includes Demodex mite density, before, during, and after 6 months of isotretinoin treatment. MATERIALS
methodsThe study included patients diagnosed with acne vulgaris and rosacea accompanied by demodicosis who were prescribed isotretinoin treatment. Demographic data were collected, and Demodex spp. mites were detected using superficial skin biopsy before treatment initiation. Follow-up samples were obtained at 2 and 6 months. Statistical analysis was performed using SPSS version 23, with a significance level set at p < 0.05.
resultsA total of 36 patients, 25 with acne and 11 with rosacea, were included in our study. Demodex density was assessed before treatment, at 2 months, and at 6 months. Our findings showed a significant decrease in Demodex density with isotretinoin treatment, especially in relation to the decrease in sebum secretion (p < 0.001).
conclusionThis study makes a notable contribution to the existing literature by being the first to assess the impact of isotretinoin treatment on Demodex density. Our results indicate that isotretinoin effectively reduces Demodex density, likely due to a reduction in sebum production. To further explore isotretinoin's effects, future research should involve larger sample sizes and extended follow-up periods. These findings enhance our understanding of isotretinoin's role in managing Demodex-related dermatological conditions.
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