Evidence map›Paper›PMID 40433670›Full record

ArticleFrontiers in cellular and infection microbiology2025

The role of periostin (OSF-2) in the cytoadherence phenomena mediated by malaria parasites.

Zhi-Ying Phong, Joo-Yie Chin, Yee Ling Ng, Nurul Izza Zakaria, Siti Nur Athirah-Azman, Varakorn Kosaisavee, Laurent Rénia, Wenn-Chyau Lee

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Ethanolic Leaf Extract ofTropical medicine and infectious disease · 2026
    Article
  3. Effect of periostin (OSF-2) on phagocytosis ofFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhi-Ying PhongDepartment of Parasitology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Joo-Yie ChinDepartment of Parasitology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Yee Ling NgCollaborative Drug Discovery Research (CDDR) Group, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Selangor, Malaysia.
Nurul Izza ZakariaDepartment of Pathology, Hospital Tengku Ampuan Afzan, Kuantan, Pahang, Malaysia.
Siti Nur Athirah-AzmanHigher Institution Centre of Excellence, Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia.
Varakorn KosaisaveeDepartment of Parasitology and Entomology, Faculty of Public Health, Mahidol University, Bangkok, Thailand.
Laurent RéniaLee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore, Singapore.
Wenn-Chyau LeeDepartment of Parasitology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The pathogenesis of severe malaria is primarily attributed to the cytoadherence properties of Methods: Laboratory-adapted Results: We found that OSF-2 at a concentration of 200 ng/ml induced rosette-stimulation in both parasite species. Furthermore, we demonstrated the serum dependency of OSF-2-mediated rosetting. The rosette-stimulating effect of OSF-2 was completely abolished when IRBC were treated with a low concentration of trypsin. This suggests a role for Discussion: This work contributes to our understanding of the host-parasite interactions in malaria pathobiology.

Indexed as

Cell AdhesionCell Adhesion MoleculesErythrocytesMalariaPlasmodium falciparumPlasmodium knowlesiHost-Parasite InteractionsHumansMalaria, FalciparumPeriostinRosette FormationCell Adhesion MoleculesPeriostinPOSTN protein, humanendothelial bindingOSF-2Plasmodium falciparumPlasmodium knowlesirosetting

Identifiers

PMID40433670
PMCPMC12106375

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.