ArticleTropical parasitology
Immunological biomarkers and their role in the diagnosis and prognosis of leishmaniasis: A case-control study.
Article in Tropical parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Different kinds of leishmaniasis can be distinguished based on the range and complexity of clinical presentations, which can vary from asymptomatic infection to severe illness that greatly affects one's quality of life. Aims of the Study: Determining the relationship between inflammatory cytokines and the severity of leishmaniasis. Methodology: A case-control study comprising 150 patients diagnosed with cutaneous leishmaniasis (75 males and 75 females) with 50 healthy controls. The individuals in question ranged in age from 35 to 45. The study was carried out at Nasiriyah General Hospital and Al-Habobbi Teaching Hospital between January 1, 2024, and August 1, 2024. Inclusion criteria required patients aged 35-45 years, with clinically confirmed leishmaniasis and positive serological results, who provided consent for participation. Exclusion criteria included individuals with immunological disorders and pregnant people. The infected group was clinically evaluated to exclude other infections or inflammatory conditions that could affect cytokine levels. Patients were categorized into mild, moderate, and severe leishmaniasis based on clinical criteria, including lesion size, number, complications, and infection duration, following established guidelines. The serum was isolated using centrifugation and preserved at a temperature of -20°C to quantify the concentrations of anti- Results: The results showed nonstatistically significant differences in mean age or gender distribution between patients and healthy controls. However, fever was more common in patients, and the severity of the disease was classified into three grades. Levels of antibodies, IFN-γ, tumor necrosis factor, IL-10, and C-reactive protein were also significantly higher in patients than in healthy controls, suggesting an association with leishmaniasis infection. Conclusions: The results confirm the relationship between levels of antibodies and immune complexes, such as IFN-γ and TNF-α, with the severity of leishmaniasis infection. These high levels indicate an intense immune response, reflecting the body's inflammatory reaction to the infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.