ArticleFrontiers in cell and developmental biology2025
Revolutionizing bone regeneration and wound healing: Mechanical stromal vascular fraction and hyaluronic acid in a mouse calvarial defect model.
Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The stromal vascular fraction (SVF) is a complex and heterogeneous suspension derived from adipose tissue, containing both cellular and noncellular components. Its cellular fraction includes adipose-derived stem cells (ASCs), endothelial precursor cells, pericytes, macrophages, lymphocytes, and smooth muscle cells. The acellular "secretome" of SVF includes bioactive molecules such as growth factors, cytokines, chemokines, extracellular vesicles, and fragments of extracellular matrix (ECM), which contribute to its regenerative potential. Bone defeatures can be stimulated by mesenchymal stem cells (MSCs) that differentiate into osteoblast to support the healing and repair process. In addition to its cell content, the SVF is rich in growth factors, cytokines and chemokines, extracellular vesicles, and extracellular matrix components, which could stimulate regenerative processes through a trophic effect. Studies showed that hyaluronic acids are usually involved in healing processes. This study was focused on the healing potency of stromal stem cells isolated from adipose tissues by mechanical digestion, and the role of low-molecular-weight hyaluronic acid (LMW-HA, ACP) in the healing process was tested in calvarial defeatures in a mouse model, in comparison with the enzymatic digestion method. Methods: The bone healing and remodeling process was evaluated Results: In this study, we explore a groundbreaking approach using HT-SVF combined with ACP to promote bone regeneration. Through comparative analysis with ED-SVF in a calvarial defect mouse model, we demonstrate the superior efficacy of HT-SVF + ACP in enhancing bone healing, reducing fibrotic tissue, and improving bone matrix maturity. Discussion: The findings establish the potential of HT-SVF as a cost-effective and efficient method for bone regenerative therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.