ArticleFrontiers in aging neuroscience2025
Multimodal neuroimaging investigation of post-stroke fatigue in middle-aged and older adults: combining resting-state fMRI and DTI-ALPS analysis.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical and preclinical evidence of meningeal immunity and glymphatic pathways in stroke: a systematic review.Frontiers in immunology · 2026Pooled it
- Multimodal MRI reveals glymphatic system activity associated with systemic inflammation and neuropsychiatric symptoms in Crohn's disease.Journal of gastroenterology · 2026Article
- Endoscopic mitral valve repair-one hundred and one ways to use neochords: a narrative review.Journal of visualized surgery · 2025Review
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Authors and funding
6 authors.
Funding
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Abstract
Background: Post-stroke fatigue (PSF) is a prevalent but often overlooked complication, particularly in middle-aged and older stroke survivors. Neuroimaging studies exploring the neural mechanisms of PSF in this age group are limited. This study aimed to identify imaging markers for PSF in middle-aged and older adults using a multimodal imaging approach. Methods: This retrospective case-control study analyzed data from patients with first ischemic stroke aged 50 years and above who were treated from January 2021 to June 2022 at the First Hospital of the University of Science and Technology of China. PSF was assessed using the Fatigue Severity Scale (FSS) and diagnostic criteria. All patients underwent resting-state functional MRI (rs-fMRI) and diffusion tensor imaging along perivascular space (DTI-ALPS) to assess brain functional connectivity and glymphatic system function. Results: The PSF group (mean age 62.7 ± 10.50 years) showed reduced global functional connectivity compared to non-fatigued controls (mean age 58.40 ± 9.20 years) ( Conclusion: This multimodal neuroimaging study highlights altered brain functional connectivity and glymphatic dysfunction as potential neural correlates of PSF in middle-aged and older adults. The findings provide novel insights into the complex pathophysiology of PSF in the aging brain, implicating both functional brain networks and the glymphatic system. Further research is warranted to validate these age-specific findings and explore targeted interventions for PSF in older stroke survivors.
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