Evidence map›Paper›PMID 40433500›Full record

ArticleFrontiers in neuroscience2025

Motor learning leverages coordinated low-frequency cortico-basal ganglia activity to optimize motor preparation in humans with Parkinson's disease.

Kara N Presbrey, Thomas A Wozny, Kenneth H Louie, Simon Little, Philip A Starr, Reza Abbasi-Asl, Doris D Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kara N PresbreyDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States.
Thomas A WoznyDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States.
Kenneth H LouieDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States.
Simon LittleDepartment of Neurology, University of California San Francisco, San Francisco, CA, United States.
Philip A StarrDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States.
Reza Abbasi-AslDepartment of Neurology, University of California San Francisco, San Francisco, CA, United States.
Doris D WangDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Learning dexterous motor sequences is crucial to autonomy and quality of life but can be altered in Parkinson's disease (PD). Learning involves optimizing pre-movement planning (preplanning) of multiple sequence elements to reduce computational overhead during active movement. However, it is unclear which brain regions mediate preplanning or how this process evolves with learning. Recording cortico-basal ganglia field potentials during a multi-day typing task in four individuals with PD, we found evidence for network-wide multi-element preplanning that improved with learning, facilitated by functional connectivity. In both cortex and basal ganglia, pre-movement gamma (

Indexed as

fine motor controlfunctional connectivityhierarchical networksmotor learningmotor planningmovement decodingParkinson’s diseasesequencing

Identifiers

PMID40433500
PMCPMC12106502

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.