ArticleJAC-antimicrobial resistance2025
Current practices in outpatient parenteral antimicrobial therapy programmes: an international multi-centre survey.
Article in JAC-antimicrobial resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Outpatient Parenteral Antimicrobial Therapy Practice Variability Across Veterans Affairs Hospitals.JAMA network open · 2026Article
- A novel meropenem dosing strategy for Outpatient Parenteral Antimicrobial Therapy (OPAT): a pilot pharmacokinetic/pharmacodynamic study in non-critically ill patients.Antimicrobial agents and chemotherapy · 2026Article
- Challenges and drivers in the implementation of current practices in outpatient parenteral antimicrobial therapy: an international survey.JAC-antimicrobial resistance · 2026Article
- 2026 Updated good practice recommendations for outpatient parenteral antimicrobial therapy (OPAT) in adults and children in the UK.JAC-antimicrobial resistance · 2026Review
- [Outpatient parenteral antimicrobial therapy: challenges and opportunities].Innere Medizin (Heidelberg, Germany) · 2026Article
- Molecular epidemiology and mechanisms ofFrontiers in microbiology · 2026Article
- Outpatient Parenteral Antimicrobial Therapy in a Tertiary Hospital in France: A Description of Service Models and Costs.Antibiotics (Basel, Switzerland) · 2025Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This study aimed to assess the current international practices of outpatient parenteral antimicrobial therapy (OPAT). Methods: A multi-site cross-sectional study was conducted, using REDCap platform for survey distribution and data collection. Data analysis was performed in SPSS version 29. Results: Of the 146 OPAT responding centres serving adults, paediatrics or both, 82% have been operating for over 10 years. OPAT teams were multidisciplinary, with nurses comprising the largest proportion in 89% of centres, followed by infectious disease (ID) pharmacists (83%) and ID physicians (80%). Service activity varied widely, with 92% centres treating fewer than 100-5000 patients annually (median = 300). Home-based models of care were used by more than 85% of facilities in Australia, the UK and Spain, while 82% of Malaysian and 75% of UK centres used infusion centres. Common OPAT indications include skin and soft tissue, bone and joint, urinary tract and respiratory tract infections, with ceftriaxone and ertapenem used by over 80% of the centres. Peripherally inserted central and midline catheters were common except in Malaysia. Among enrolled centres, complex oral antimicrobial therapy supervision was higher in the UK (82%) than in Spain (77%), Australia (42%) and Malaysia (24%). Inconsistencies in guidelines supporting antimicrobial stability and dosing information were noted, with a call for more stability data on certain antimicrobials. Conclusions: This study revealed significant variation in OPAT practice. Further study is needed to understand the reasons for these differences and whether better alignment of practice could improve patient outcomes, antimicrobial stewardship practice and resource utilization.
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