ReviewIranian journal of medical sciences2025
Uncovering Novel Anti-Lung Cancer Compounds: Insights from Marine Sponge-Derived Agents: A Bibliometric Review.
Review in Iranian journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Oxidoreductase Activity of a Stable Multi-protein Complex from the Sea Cucumber Eupentacta fraudatrix.The protein journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lung cancer remains a leading cause of cancer-related mortality, necessitating improved treatment strategies. This study collectively highlights the valuable potential of marine sponges as a source for discovering new anti-tumor agents. Methods: We conducted a bibliometric analysis to identify anticancer compounds from marine sponges using PubMed (2018-2023). The search included keywords such as "marine sponge," "cancer," "neoplasm," "proliferation," "cytotoxicity," "tumor," "sesquiterpene," "alkaloid," and "quinones." Inclusion criteria focused on studies related to lung cancer and marine sponge-derived compounds, excluding non-cytotoxic activities and unrelated species. Data were extracted in comma-separated values (CSV) format and analyzed via VOSviewer. Molecular docking identified compounds with strong binding to apoptotic receptors in lung cancer cells. PROTOX and Way2Drug tools predicted the pharmacological properties of selected compounds as potential drugs. Results: The bibliometric analysis identified alkaloids, sesquiterpenes, and quinones as key keywords. Dactyloquinone B-D, dysidavarone D, smenohamien F, and sollasin E demonstrated strong binding to apoptotic receptors in lung cancer cells, suggesting potential as anti-lung cancer drugs. Pharmacological analyses revealed promising effects and potential side effects, highlighting their suitability for further drug development. These findings provide a foundation for novel targeted therapies for lung cancer. Conclusion: This study highlights the potential of alkaloids and sesquiterpenes derived from marine sponges as promising anti-lung cancer agents, emphasizing the need for further
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.