Evidence map›Paper›PMID 40433115›Full record

ArticleBrain communications2025

Delineating network integration and segregation in the pathophysiology of functional neurological disorder.

Christiana Westlin, Andrew J Guthrie, Cristina Bleier, Sara A Finkelstein, Julie Maggio, Jessica Ranford, Julie MacLean, Ellen Godena, Daniel Millstein, Sara Paredes-Echeverri and 5 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Christiana WestlinFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0001-9127-0847
Andrew J GuthrieFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Cristina BleierFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Sara A FinkelsteinFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Julie MaggioFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Jessica RanfordFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Julie MacLeanFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Ellen GodenaFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Daniel MillsteinFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Sara Paredes-EcheverriFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Jennifer FreeburnFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Caitlin AdamsFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Christopher D StephenFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0002-4727-192X
Ibai DiezFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
David L PerezFunctional Neurological Disorder Research Group, Department of Neurology, Massachusetts General Hospital, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0003-2721-583X

Funding

Defining Neurobiological Subtypes of Motor Functional Neurological DisorderR01MH125802 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI PEREZ, DAVID LEWIS · 2021 to 2025
$3.9M
NIMH NIH HHS R01 MH125802
6 · The paper itself

Abstract

Functional neurological disorder (FND) is a neuropsychiatric condition that is framed as a multi-network brain problem. Despite this conceptualization, studies have generally focused on specific regions or connectivity features, under-characterizing the complex and nuanced role of resting-state networks in FND pathophysiology. This study employed three complementary graph theory analyses to delineate the functional network architecture in FND. Specifically, we investigated whole-brain weighted-degree, isocortical integration and isocortical segregation extracted from resting-state functional MRI data prospectively collected from 178 participants: 61 individuals with mixed FND; 58 psychiatric controls matched on age, sex, depression, anxiety and post-traumatic stress disorder severity; and 59 age- and sex-matched healthy controls. All analyses were adjusted for age, sex and antidepressant use and focused on differences between FND versus psychiatric controls, with individual-subject maps normalized to healthy controls. Compared to psychiatric controls, patients with mixed FND exhibited increased weighted-degree in the right dorsal anterior cingulate and superior frontal gyrus and the left inferior frontal gyrus and supplementary motor area. Isocortical integration analyses revealed increased

Indexed as

functional neurological disordergraph theoryintegrationresting-state fMRIsegregation

Identifiers

PMID40433115
PMCPMC12107243

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.