Evidence map›Paper›PMID 40433108›Full record

ArticleReproductive medicine and biology

KIF2C Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice.

Hiroaki Kitakaze, Haruhiko Miyata, Yuki Oyama, Chen Pan, Yuma Kujime, Go Tsujimura, Takahiro Imanaka, Sohei Kuribayashi, Norichika Ueda, Kentaro Takezawa and 3 more

Abstract read
In one paragraph

Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hiroaki KitakazeResearch Institute for Microbial Diseases The University of Osaka Osaka Japan.ORCID https://orcid.org/0009-0002-8421-7911
Haruhiko MiyataResearch Institute for Microbial Diseases The University of Osaka Osaka Japan.ORCID https://orcid.org/0000-0003-4758-5803
Yuki OyamaResearch Institute for Microbial Diseases The University of Osaka Osaka Japan.
Chen PanResearch Institute for Microbial Diseases The University of Osaka Osaka Japan.
Yuma KujimeDepartment of Urology, Graduate School of Medicine The University of Osaka Osaka Japan.
Go TsujimuraDepartment of Urology, Graduate School of Medicine The University of Osaka Osaka Japan.
Takahiro ImanakaDepartment of Urology, Graduate School of Medicine The University of Osaka Osaka Japan.
Sohei KuribayashiDepartment of Urology, Graduate School of Medicine The University of Osaka Osaka Japan.ORCID https://orcid.org/0000-0002-0564-6404
Norichika UedaDepartment of Urology, Graduate School of Medicine The University of Osaka Osaka Japan.
Kentaro TakezawaDepartment of Urology, Graduate School of Medicine The University of Osaka Osaka Japan.ORCID https://orcid.org/0000-0003-1137-1846
Shinichiro FukuharaDepartment of Urology, Graduate School of Medicine The University of Osaka Osaka Japan.
Norio NonomuraDepartment of Urology, Graduate School of Medicine The University of Osaka Osaka Japan.
Masahito IkawaResearch Institute for Microbial Diseases The University of Osaka Osaka Japan.ORCID https://orcid.org/0000-0001-9859-6217

Funding

Functional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5M
NICHD NIH HHS R01 HD088412
6 · The paper itself

Abstract

Purpose: Kinesin Family Member 2C (KIF2C) is a key regulator of microtubule dynamics and chromosome segregation in mitosis. However, its role in spermatogenesis remains unclear. Recent transcriptomic analyses suggest a potential link between KIF2C and male infertility. This study aimed to clarify KIF2C's roles in spermatogenesis using Methods: To overcome the preweaning lethality associated with Results: Global Conclusions: This study provides in vivo evidence that KIF2C is essential for spermatogenesis and male fertility in mice. The successful generation of global

Indexed as

KIF2Cknockout micemale infertilitynonobstructive azoospermia

Identifiers

PMID40433108
PMCPMC12107603

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.