ReviewRSC advances2025
Advances in steroid purification for novel techniques in carbon isotope ratio mass spectrometry of doping control.
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Annual Banned-Substance Review 18th Edition-Analytical Approaches in Human Sports Drug Testing 2024/2025.Drug testing and analysis · 2026Review
- Analysis of metabolic characteristics of epristeride in zebrafish based on LC-Q-TOF MS and its potential applications in doping control.RSC advances · 2026Article
- Adulteration of Sports Supplements with Anabolic Steroids-From Innocent Athlete to Vicious Cheater.Nutrients · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Doping detection is a critical tool for maintaining fairness in competitive sports. Steroids are widely abused due to their ability to promote protein synthesis, enhance muscle growth, and improve athletic performance, leading to significant unfair competition. Carbon isotope ratios (CIRs) are effective in distinguishing between endogenous and exogenous steroid sources, making steroids an ideal target for isotope ratio analysis in anti-doping analysis. High-precision isotope ratio measurements using Gas Chromatography-Isotope Ratio Mass Spectrometry (GC-IRMS) require high separation between the target steroid and adjacent compounds to avoid interference. However, steroid concentrations in biological matrices like urine and blood are often trace and accompanied by a large number of coexisting interferents, making purification challenging. These limitations have partially restricted the use of compound-specific isotope analysis in doping detection. This review highlights the latest advancements over the past decade in sample preparation, liquid-phase purification, and both gas-phase and liquid-phase isotope ratio mass spectrometry (IRMS) techniques. By summarizing the application of these methods in anti-doping efforts and exploring future research directions, this review aims to enhance the precision and reliability of steroid doping detection technologies, providing scientific support for anti-doping efforts and identifying the abuse of steroids.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.