ArticleRSC advances2025
Green synthesis of structural analogs of favipiravir.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A series of 3-hydroxy-5-arylpyrazine-2-carboxamides, structural analogs of favipiravir, have been successfully synthesized using a green and sustainable method through a one-pot condensation reaction of arylglyoxals 1a-i and 2-aminopropanediamide 2 in an alkaline solution under heating conditions. The reaction is temperature-sensitive; when conducted at 80 °C, 5-aryl substituted pyrazine derivatives were predominantly obtained. In reactions with arylglyoxals 1a, 1d, 1h, and 1i, temperatures exceeding 80 °C produced a mixture of two regioisomeric pyrazine derivatives with significant efficiency. This method is highly desirable due to its short reaction time, simple purification of products, and the use of water as an eco-friendly solvent.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.