ArticleRSC advances2025
Synthesis of an amphiphilic bi-prodrug based on gossypol and cytarabine for drug self-delivery.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug-drug conjugates have become a research hotspot in nanomedicine. An amphiphilic assembled drug-drug conjugate can achieve drug self-delivery without any carriers and change the distribution of free drugs. Herein, we synthesized a pH-responsive bi-prodrug of gossypol (GP) and cytarabine (Ara-C) for cancer therapy. FT-IR, UV-vis, TLC and MS confirmed that GP-Ara-C was successfully synthesized. The nanoparticle size of GP-Ara-C is approximately 100 nm, and the stability of GP-Ara-C is maintained for 6 days in pH 7.4 phosphate-buffered saline (PBS). HeLa cell viability results showed that GP-Ara-C exhibited anticancer ability similar to that of free GP. Cellular uptake demonstrated that GP-Ara-C could be distributed in cell nuclei at 7 h. Altogether, this amphiphilic GP-Ara-C could be assembled into nanomedicine in an aqueous environment and could be a candidate for cancer therapy in clinics.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.