ArticleRSC advances2025
Biomimetic trilayered silk-based electrospun scaffolds for regeneration of dura mater.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Complex bioactive nanofibrous dura mater repairs traumatic brain injury.Neural regeneration research · 2026Article
- Development of bioactive SF/HAp/ZnO scaffolds incorporating succinic acid with potential bone regeneration capabilities.RSC advances · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dura mater healing is essential to prevent cerebrospinal fluid (CSF) leaks in neurosurgical procedures. Drawing inspiration from the hierarchical structure of native dura mater, we have designed a biomimetic electrospun trilayered scaffold (TLS) utilizing silk fiber to replicate both the structure and function of the original tissue. The electrospun trilayered scaffold comprises three distinct layers: a skull-facing layer constructed from silk fibroin combined with strontium-doped bioactive glass, a gradient inert polyurethane middle layer and a brain-facing layer consisting of polyurethane infused with oregano essential oil. For the first time, oregano essential oil is used in dural substitute to impart potential antibacterial properties. The physicochemical properties of TLS were systematically evaluated using Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM), microcomputed tomography (micro-CT) and thermogravimetric analysis. The nanoscale architecture was verified through SEM while micro-CT analysis provided additional insights into the fibrous surfaces of the trilayered scaffold. Surface wettability tests revealed that the wetting characteristics were comparable to those of the native dura mater, with the brain-facing layer exhibiting hydrophobic properties conducive to water-tight dural closure and the skull-facing layer presenting hydrophilic properties favorable for cell adhesion. After immersion in phosphate-buffered saline (PBS) for 28 days, the TLS showed a degradation rate of 13%. Furthermore, the results show that TLS was porous (60%) and demonstrated improved swelling in PBS. The addition of OEO improved the antibacterial potential; the TLS exhibited 80% antibacterial activity against
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.