ArticleFrontiers in microbiology2025
Identification and bioinformatics analysis of cilia-associated gene families in
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Detection and functional analysis of horizontal gene transfer events in the ciliateFrontiers in microbiology · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
Introduction: Ciliates serve as pivotal model organisms for investigating the protein composition and regulatory mechanisms underlying cellular processes. This study systematically explores the structural and functional characteristics of cilia-associated genes in Methods: The macronuclear genome of Results: A total of 418 cilia-associated genes were identified, with 44 conserved across the four hypotrich ciliate species. Functional categorization revealed kinases, dyneins, tubulins, and autophagy-related proteins. Pfam annotations predicted three conserved domains. GO terms were enriched in tubulin binding, cilia assembly, and microtubule-based movement. Pathway analysis implicated these genes in adenine ribonucleotide biosynthesis, glycolysis/gluconeogenesis, Wnt, and AMP-activated protein kinase (AMPK) signaling. QPCR showed significant downregulation of cilia-related proteins during mitosis. RNAi of ARL2BP and DYNLRB2 increased mortality, reduced motility, and disrupted cortical microtubule organization via immunofluorescence. Thirty-nine hub genes were strongly linked to ciliopathies. Discussion: Cilia-associated genes in
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