ArticleFrontiers in oncology2025
Case Report: Retroperitoneal dedifferentiated solitary fibrous tumor with unexpected Pax-2 expression, mimicking high grade clear cell renal cell carcinoma.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Here, we report a case of retroperitoneal solitary fibrous tumor (SFT) in a 69-year-old Chinese woman. The patient had experienced lumbodorsal pain for more than two years. A computed tomography (CT) scan showed a mass adjacent to the right kidney, invading the surrounding soft tissues, measuring about 9.3 × 8.4 cm. An incision biopsy was performed. Microscopically, the tumor was composed of sheets of epithelioid cells with round to ovoid nuclei, and abundant clear cytoplasm. The cells showed severe nuclear atypia and brisk mitosis, with thin-walled branched blood vessels set against a myxoid to collagenous background. By immunohistochemistry, the tumor cells exhibited diffuse and strong expression of CK-pan, Pax-2, P53, INI-1 and H3K27me3. Staining for CD34, S100, SOX10, TLE1, WT-1, and CK5/6 was negative. STAT6 staining was weak and indistinct. Furthermore, next generation sequencing (NGS) disclosed a rare
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