Evidence map›Paper›PMID 40432740›Full record

ArticleYonago acta medica2025

5-Aminolevulinic Acid-Mediated Metronomic Photodynamic Therapy for Mouse Mammary Tumors.

Tomohiro Osaki, Hikaru Shiomi, Takahiro Nishimura, Kei Sakanoue, Kazuhiro Eguchi, Yutaka Miyazono, Ryoichi Yamaguchi, Katsuhiko Fujita, Kenji Kuwata, Naoki Kobayashi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Yonago acta medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tomohiro OsakiJoint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
Hikaru ShiomiJoint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
Takahiro NishimuraGraduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Kei SakanouePleiades Technologies LLC, Fukuoka 814-0001, Japan.
Kazuhiro EguchiPleiades Technologies LLC, Fukuoka 814-0001, Japan.
Yutaka MiyazonoPleiades Technologies LLC, Fukuoka 814-0001, Japan.
Ryoichi YamaguchiKumamoto Industrial Research Institute, Kumamoto 862-0901, Japan, ||Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka 816-8580, Japan.
Katsuhiko FujitaInstitute for Materials Chemistry and Engineering, Kyushu University, Fukuoka 816-8580, Japan.
Kenji KuwataNIPPON SHOKUBAI CO., LTD., Osaka 541-0043, Japan.
Naoki KobayashiNIPPON SHOKUBAI CO., LTD., Osaka 541-0043, Japan.
Tsuyoshi GoyaNIPPON SHOKUBAI CO., LTD., Osaka 541-0043, Japan.
Katsuyuki MoriiNIPPON SHOKUBAI CO., LTD., Osaka 541-0043, Japan.
Urara OtaSBI Pharmaceuticals Co., Ltd., Tokyo 106-6013, Japan.
Hideo ImazatoSBI Pharmaceuticals Co., Ltd., Tokyo 106-6013, Japan.
Kiwamu TakahashiSBI Pharmaceuticals Co., Ltd., Tokyo 106-6013, Japan.
Masahiro IshizukaSBI Pharmaceuticals Co., Ltd., Tokyo 106-6013, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Metronomic photodynamic therapy (mPDT) is a novel cancer treatment strategy that uses low-dose light delivery and photosensitizers. 5-aminolevulinic acid (5-ALA), a precursor of protoporphyrin IX (PpIX) was previously used to treat human colorectal and esophageal cancer cells. However, no study has evaluated the efficacy of 5-ALA-mPDT using light of different wavelengths. Therefore, we evaluated cytotoxicity induced by 5-ALA-PDT and the antitumor effect of 5-ALA-mPDT. Methods: In an Results: In the Conclusion: Considering the results of our

Indexed as

5-aminolevulinic acidmammary tumormetronomic photodynamic therapymouseorganic light-emitting diode

Identifiers

PMID40432740
PMCPMC12104577

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.