SynthesisFrontiers in medicine2025
Effectiveness of biofeedback therapy on low anterior resection syndrome: a systemic review with meta-analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does robotic intersphincteric resection better preserve anal function in low rectal cancer: a systematic review and meta-analysis?Frontiers in medicine · 2026Pooled it
- Distinct trajectories of low anterior resection syndrome following ileostomy reversal.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: As a series of bothersome bowel dysfunction symptoms, low anterior resection syndrome (LARS) has a high incidence after rectal cancer surgery, which grievously impairs health-related quality of life. There have been an increasing number of studies on biofeedback therapy (BFT) to recover intestinal function in patients following anus-preserving surgery. However, few systematic reviews or meta-analyses have been reported. Objective: The purpose of this systematic review with meta-analysis was to identify the short-term and long-term effects of BFT on subjective and objective indicators of LARS. Methods: Randomized controlled trials (RCT) published in PubMed, Cochrane Library, Web of Science, Embase, Chinese National Knowledge Infrastructure (CNKI), Wan Fang Data, China Biology Medicine disc (CBM), and Wei Pu (VIP) database from January 2012 to June 2024 were systematically searched. In accordance with PRISMA guidelines, the pooled findings were examined by Review Manager version 5.4. Results: The review finally included 14 RCT studies, with a total of 1,126 relevant patients. The meta-analysis results showed that following BFT, the mean resting pressure of the anal canal (MD = 5.53; 95% CI: 2.57, 8.49; Z = 3.66; Conclusion: Our systematic review and meta-analysis indicate that BFT may improve the mean resting pressure of the anal canal and the mean initial rectal sensation threshold, reducing the incidence rate of LARS. Still, high-quality studies are necessary to explore the BFT standard for LARS. Systematic review registration: PROSPERO: CRD42024519785, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024519785.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.