ArticleCureus2025
A Case of Bilateral Acro-Osteolysis Following Osteomyelitis in a Patient With Type 2 Diabetes Mellitus and a Literature Review on Acro-Osteolysis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Acro-osteolysis is a rare condition characterised by progressive resorption of the distal phalanges, often associated with systemic diseases, neuropathy, or vascular dysfunction. While commonly linked to autoimmune and rheumatic conditions, its occurrence in diabetic patients following osteomyelitis is infrequent. We present a case of bilateral acro-osteolysis in a male in his mid-70s with type 2 diabetes mellitus and a history of chronic osteomyelitis. Despite appropriate antimicrobial management, the patient exhibited ongoing bone resorption in both feet. A comprehensive autoimmune and vascular workup ruled out alternative causes, supporting the diagnosis of acro-osteolysis secondary to chronic infection. This case highlights the diagnostic challenges and potential mechanisms of acro-osteolysis in diabetic patients. Early recognition and a multidisciplinary approach are crucial to preventing functional disability.
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