ArticleMovement disorders : official journal of the Movement Disorder Society2025
Neural Mechanisms of Object Location Memory in Huntington's Disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Visuospatial working memory in Huntington's disease: behavioural and structural brain correlates.Journal of neurology, neurosurgery, and psychiatry · 2026Article
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5 authors.
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Abstract
backgroundObject-location memory impairment in Huntington's disease (HD) occurs from premanifest period and declines as HD progresses, however, pathogenesis of object-location memory is unknown. The striatum and hippocampus are affected in HD, functionally interacting allowing intact object-location memory.
objectivesThe present study investigated if object location memory impairment in premanifest and manifest HD was associated with aberrations in effective connectivity between striatum and hippocampal formation.
methodsUsing dynamic causal modelling, we examined effective connectivity between the striatum and hippocampus and association with object-location memory in 35 HD participants (23 premanifest, 12 early manifest) and 32 controls.
resultsHD participants' object-location memory was worse than controls, with performance associated with aberrant effective connectivity from the striatum to hippocampal formation, lower connectivity was associated with poorer object-location memory. Connectivity from hippocampal formation to the striatum was lower in manifest HD. In premanifest HD, connectivity from parahippocampal gyrus to the striatum was stronger and associated with better object-location memory.
conclusionsFindings raise questions regarding compensatory neural processes in HD and other neurodegenerative diseases, providing pathophysiological evidence that cognitive impairment may be related to connectopathy. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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