Evidence map›Paper›PMID 40432562›Full record

Trial reportMovement disorders clinical practice2025

Efficacy and Safety of Electroacupuncture on Insomnia in Parkinson's Disease: A Multicentre, Randomized, Controlled Trial.

Si-Chun Gu, Ping Yin, Min Yang, Rong Shi, Qiang Li, Jun Liu, Yun-Cheng Wu, Yu Zhang, Chang-De Wang, Yun-Yun Zhang and 7 more

Abstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Si-Chun Gu *Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ping Yin *Sleep Medicine Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Min Yang *Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Rong ShiDepartment of Emergency, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Qiang LiDepartment of Neurology, Gongli Hospital, Shanghai, China.
Jun LiuDepartment of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yun-Cheng WuDepartment of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yu ZhangDepartment of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chang-De WangDepartment of Neurology, Shanghai TCM-integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yun-Yun ZhangDepartment of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Min-Jue GuDepartment of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Li-Min XuDepartment of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chen GaoDepartment of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xiao-Lei YuanDepartment of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
You WuDepartment of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Can-Xing YuanDepartment of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Qing YeDepartment of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID 0009-0002-4453-6360

Funding

Shanghai Municipal Health Commission 2024QN046Shanghai Science and Technology Development Foundation 21Y31920300Shanghai Shenkang Hospital Development Center SHDC2023CRD005
6 · The paper itself

Abstract

backgroundSleep disturbances, particularly insomnia, are prevalent and debilitating non-motor symptoms of Parkinson's disease (PD), significantly impacting quality of life. Current treatment options are limited by side effects and accessibility. Electroacupuncture (EA), a non-pharmacological approach, has shown promise in insomnia, while its specific impact on insomnia in PD remains unexplored.

objectivesTo determine the efficacy and safety of EA vs sham electroacupuncture (SA) on insomnia associated with PD.

methodsWe conducted a multicenter, participant-and assessor-blinded, randomized, sham-controlled clinical trial from March 1, 2024, to October 28, 2024, across eight sites in China. A total of 136 PD patients with insomnia were assigned to receive EA or SA (68 per arm) over an 8-week treatment period followed by a 12-week follow-up period. The primary outcome was the change in Parkinson's Disease Sleep Scale (PDSS) scores at week 8. A range of subjective sleep-related metrics and objective sleep assessments derived from polysomnography were utilized as secondary outcomes.

resultsBoth groups showed significant improvements in PDSS scores, with the EA group demonstrating a greater effect (between-group difference, 13.50 [95%CI, 12.68 to 14.32]). Secondary outcomes, including Insomnia Severity Index, Epworth Sleepiness Scale, and polysomnography-derived parameters, also showed greater improvements in EA group. The effects were maintained during the 12-week follow-up with no severe adverse events. The blinding assessment confirmed successful blinding.

conclusionsEA was effective in improving insomnia and related sleep disturbances in PD. This study provided Class I evidence supporting the integration of EA into the treatment regimen for insomnia in PD.

Indexed as

ElectroacupunctureParkinson DiseaseSleep Initiation and Maintenance DisordersAgedFemaleHumansMaleMiddle AgedQuality of LifeTreatment OutcomeelectroacupunctureinsomniaParkinson's diseasepolysomnographysleep disturbances

Identifiers

PMID40432562
PMCPMC12528969

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.