ArticleJournal of medical virology2025
Human Papillomavirus Genotyping and Viral Load as a Predictor of Cervical Lesions: A Prospective Study.
Article in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Coumarin Compounds with 6- or 7-(4-Aminobutynyloxy) Substituent: Synthesis, In Vitro Cytotoxicity and In Silico DNA Binding Studies.Molecules (Basel, Switzerland) · 2026Article
- Regression of high-grade squamous intraepithelial lesions in women aged 30 years or younger: a retrospective cohort study.Journal of cancer research and clinical oncology · 2026Article
- Bidirectional Interactions Between Cervicovaginal Microbiota and Human Papillomavirus Drive Persistence and Disease Progression.International journal of molecular sciences · 2026Review
- Negative Xpert HPV Test (Cepheid) With Late Amplification Signals: Is There a Clinical Significance? (the PaPCR Study).Journal of medical virology · 2026Article
- Review
- A Retrospective Analysis of Atypical Cervical Cytology: Correlating Bethesda Categories with HPV Genotyping and Histological Follow-Up.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
This prospective study aims to examine the impact of changes in viral load on the occurrence of cervical lesions and to evaluate viral load as a biomarker for predicting cervical lesions and triaging HPV-positive patients. From September 2022 to August 2023, 1150 women aged 25-60 were enrolled at the Changzhou Maternal and Child Health Hospital. All participants tested positive for HPV and negative for both cytology and pathology. A follow-up was conducted 6 months later to reassess HPV status and perform colposcopy. BMRT was employed to detect various HPV types and their viral loads. The ROC curve was utilized to determine the viral load cut-off values for different HPV types to predict cervical lesions. From baseline to follow-up, women whose HPV infection cleared were significantly younger than those with persistent HPV infection (p < 0.001). At baseline, the viral loads of the virus clearance, maintenance, and progression groups demonstrated an increasing trend (p < 0.001). Among women diagnosed with CIN during follow-up, the viral load increased significantly from baseline to follow-up (p = 0.001). The combination of HPV genotyping and viral load in the initial screening of cervical cancer enhances the prediction and identification of cervical lesions.
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Registered trials
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