Evidence map›Paper›PMID 40432265›Full record

ArticleEuropean journal of neurology2025

Cardiac Events After Mechanical Thrombectomy in Acute Ischemic Stroke: A Nation-Wide Cohort Study.

Nicolaj Grønbæk Laugesen, Jakob Nebeling Hedegaard, David Gaist, Claus Ziegler Simonsen, Boris Modrau, Klaus Hansen, Søren Paaske Johnsen, Thomas Truelsen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicolaj Grønbæk LaugesenCerebrovascular Research Unit Rigshospitalet, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Jakob Nebeling HedegaardDanish Centre for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
David GaistResearch Unit for Neurology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Claus Ziegler SimonsenDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Boris ModrauDepartment of Neurology, Aalborg University Hospital, Aalborg, Denmark.
Klaus HansenCerebrovascular Research Unit Rigshospitalet, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Søren Paaske JohnsenDanish Centre for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Thomas TruelsenCerebrovascular Research Unit Rigshospitalet, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Funding

A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal L-2023-00171Novo Nordisk Fonden 65517Rigshospitalet E-24087-01
6 · The paper itself

Abstract

introductionMechanical thrombectomy (MT) markedly improves the outcome in patients with large vessel occlusion stroke. Given the cardiovascular risk profile of these patients, we wanted to investigate their post-MT risk of cardiac events compared to other patients with acute ischemic stroke (AIS).

methodsAll hospitalizations for AIS in Denmark from 2014 to 2021 were included in this registry-based cohort study. Patients were categorized by reperfusion treatment: MT with or without intravenous thrombolysis (IVT), IVT alone, or no reperfusion treatment (NRT). Cardiac events included ischemic heart disease, heart failure, or cardiac death within 6 months of AIS. Pair-wise group comparisons were performed after inverse probability treatment weighting (IPTW).

resultsAmong 76,092 AIS patients, 4.4% received MT, 15.2% received IVT alone, and 80.4% received NRT. In the MT group, 9.6% of patients experienced cardiac events. After IPTW, MT patients had the highest risk of cardiac events compared to IVT (absolute risk difference [ARD] 4.6%, cause-specific hazard rate ratio [HRR] 1.42 [95% CI: 1.27-1.60]) and NRT (ARD 4.6%, HRR 1.35 [95% CI: 1.22-1.49]). Pre-existing cardiac disease was similar across groups (9.2%-11.8%) and after exclusion of patients with prior cardiac disease, the HRR of cardiac events remained consistent with the primary analysis (MT vs. IVT: HRR 1.48 [95% CI: 1.31-1.68]; MT vs. NRT: 1.39 [95% CI: 1.24-155]).

conclusion10% of patients with AIS undergoing MT experienced cardiac events within 6 months compared to 5% of other AIS patients. This study identified an unrecognized burden of cardiac disease in this group of AIS patients treated with MT.

Indexed as

Ischemic StrokeThrombectomyAgedAged, 80 and overCohort StudiesDenmarkFemaleHumansMaleMiddle AgedRegistriesThrombolytic TherapyAIScardiac eventscerebrovascular disordersheart disease after strokereperfusion treatmentstrokestroke‐heart syndromethrombectomy

Identifiers

PMID40432265
PMCPMC12116937

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.