Evidence map›Paper›PMID 40432238›Full record

ReviewBiochemistry2025

Iron-Sulfur Cluster Enzymes of the Methylerythritol Phosphate Pathway: IspG and IspH.

Andrew Douw, Jordi Perez-Gil, Gerhard Schenk, Claudia E Vickers

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Substitution of CHChemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew DouwSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
Jordi Perez-GilARC Centre of Excellence in Synthetic Biology, Australian Genome Foundry, and School of Natural Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.
Gerhard SchenkSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.ORCID 0000-0001-8619-0631
Claudia E VickersARC Centre of Excellence in Synthetic Biology, Centre for Agriculture and the Bioeconomy, and School of Environment and Biological Sciences, Queensland University of Technology, Brisbane, Queensland 4000, Australia.ORCID 0000-0002-0792-050X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron-sulfur cluster (Fe-S) enzymes catalyze important biological processes in cellular metabolism. They evolved in the preoxic world and are oxygen sensitive; biology has therefore evolved a range of mechanisms to protect them from oxidative damage. The 2-

Indexed as

ErythritolEscherichia coli ProteinsIron-Sulfur ProteinsOxidoreductasesSugar Phosphates2-C-methylerythritol 4-phosphateErythritolEscherichia coli ProteinsIron-Sulfur ProteinsispH protein, E coliOxidoreductasesSugar PhosphatesHDRHDSiron−sulfur clusterIspGIspHMEP pathwayreactive oxygen species

Identifiers

PMID40432238
PMCPMC12178251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.