Evidence map›Paper›PMID 40432099›Full record

ArticleVaccines2025

Safety and Immunogenicity of the Attenuated Yellow Fever Vaccine in Several Neotropical Primate Species.

Nayara Ferreira de Paula, André Duarte Vieira, Daniel Oliveira Dos Santos, Lucas Dos Reis de Souza, Carlyle Mendes Coelho, Herlandes Penha Tinoco, Paula Cristina Senra Lima, Rafael Otávio Cançado Motta, Valéria do Socorro Pereira, Marcelo Pires Nogueira de Carvalho and 10 more

Abstract read
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Nayara Ferreira de PaulaDepartamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil.
André Duarte VieiraDepartamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil.ORCID 0000-0002-5283-2429
Daniel Oliveira Dos SantosDepartamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil.
Lucas Dos Reis de SouzaDepartamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil.ORCID 0000-0003-1685-5348
Carlyle Mendes CoelhoFundação de Parques Municipais e Zoobotânica, Jardim Zoológico, Av. Otacílio Negrão de Lima 8000, Belo Horizonte 31365-450, Brazil.
Herlandes Penha TinocoFundação de Parques Municipais e Zoobotânica, Jardim Zoológico, Av. Otacílio Negrão de Lima 8000, Belo Horizonte 31365-450, Brazil.
Paula Cristina Senra LimaFundação de Parques Municipais e Zoobotânica, Jardim Zoológico, Av. Otacílio Negrão de Lima 8000, Belo Horizonte 31365-450, Brazil.
Rafael Otávio Cançado MottaFundação de Parques Municipais e Zoobotânica, Jardim Zoológico, Av. Otacílio Negrão de Lima 8000, Belo Horizonte 31365-450, Brazil.
Valéria do Socorro PereiraFundação de Parques Municipais e Zoobotânica, Jardim Zoológico, Av. Otacílio Negrão de Lima 8000, Belo Horizonte 31365-450, Brazil.
Marcelo Pires Nogueira de CarvalhoDepartamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil.
Camilla Bayma FernandesFundação Oswaldo Cruz, Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Av. Brasil 4365, Rio de Janeiro 21040-900, Brazil.
Adriana de Souza AzevedoFundação Oswaldo Cruz, Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Av. Brasil 4365, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0001-7401-5107
Matheus Soares ArrudaDepartamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil.ORCID 0000-0001-5869-2183
Thais Alkifeles CostaDepartamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil.
Betania Paiva DrumondDepartamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil.
Fabiola de Oliveira Paes LemeDepartamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil.
Marcos da Silva FreireFundação Oswaldo Cruz, Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Av. Brasil 4365, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-4723-8994
Tatiane Alves da PaixãoDepartamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil.ORCID 0000-0001-8284-9902
Ayisa Rodrigues OliveiraDepartamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil.
Renato Lima SantosDepartamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil.ORCID 0000-0002-4830-0470

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 310088/2023-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior N/AFundação de Amparo a Pesquisa do Estado de Minas Gerais APQ-01972-23Morris Animal Foundation D24ZO-349
6 · The paper itself

Abstract

BACKGROUND/

objectiveYellow fever (YF) is an acute infectious disease caused by the yellow fever virus which is transmitted by mosquitoes. Neotropical primates are susceptible to infection, which is often presented as epizootic outbreaks. The aim was to evaluate and characterize the immune response against YF in different species of neotropical primates from the Belo Horizonte Zoo.

methodsVaccine 17DD was administered to 24 neotropical primates, with a single subcutaneous dose. Clinical exams, RNAemia, and detection of IgG and neutralizing antibodies against YFV were performed. In addition, an ethogram was performed to assess clinical changes and animal welfare.

resultsAt 4 days post-vaccination, RNAemia was detected in nine animals. There was seroconversion and persistence of immune response in

conclusionsThis study demonstrated a safe, immunogenic and persistent immune response induced by the attenuated 17DD vaccine strain in

Indexed as

17DDflavivirusneutralizing antibodiesnon-human primatesRNAemiavaccinationyellow feveryellow fever virus

Identifiers

PMID40432099
PMCPMC12116081

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.