Evidence map›Paper›PMID 40432080›Full record

ArticleVaccines2025

A Cyclic-di-AMP Adjuvanted CPAF Protein Vaccine Is Immunogenic in Swine, but It Fails to Reduce Genital

Leonie Bettin, Maria Stadler, Christine Unterweger, Maximiliane Dippel, Jonathan M Harris, Andrea Buzanich-Ladinig, Taylor B Poston, Toni Darville, Tobias Käser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. AFrontiers in immunology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leonie BettinDepartment of Biological Sciences and Pathobiology, Center of Pathobiology, Immunology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
Maria StadlerDepartment of Biological Sciences and Pathobiology, Center of Pathobiology, Immunology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
Christine UnterwegerClinical Department for Farm Animals and Food System Science, Clinical Centre for Population Medicine in Fish, Pig and Poultry, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.ORCID 0000-0003-4965-2088
Maximiliane DippelClinical Department for Farm Animals and Food System Science, Clinical Centre for Population Medicine in Fish, Pig and Poultry, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
Jonathan M HarrisCentre for Immunology and Infection Control, Queensland University of Technology, Brisbane, QLD 4000, Australia.ORCID 0000-0003-4209-2380
Andrea Buzanich-LadinigClinical Department for Farm Animals and Food System Science, Clinical Centre for Population Medicine in Fish, Pig and Poultry, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.ORCID 0000-0001-5037-7269
Taylor B PostonDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-5985-4153
Toni DarvilleDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Tobias KäserDepartment of Biological Sciences and Pathobiology, Center of Pathobiology, Immunology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.ORCID 0000-0001-8764-7971

Funding

Development of a Chlamydia trachomatis Vaccine in an Outbred Pre-exposed Swine Animal ModelR01AI162709 · NIAID · VETERINARMEDIZINISCHE UNIVERSITAT WIEN · PI KAESER, TOBIAS E · 2021 to 2025
$2.2M
NIAID NIH HHS R01 AI162709NIH HHS 7R01AI162709-03
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adjuvantanimal modelc-di-AMPchlamydial-protease-like activity factorChlamydia trachomatispigsSTING agonistvaccination

Identifiers

PMID40432080
PMCPMC12115861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.